Results 71 to 80 of about 469,904 (306)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Frontiers in Microbiology, 2016 The ability of plant viruses to propagate their genomes in host cells depends on many host factors. In the absence of an agrochemical that specifically targets plant viral infection cycles, one of the most effective methods for controlling viral diseases
Masayoshi Hashimoto +3 more
doaj +1 more source
Resistant and susceptible pea lines harbour different root-rot pathogens and antagonistic fungi [PDF]
, 2019 Disease resistance encompasses the mechanisms that allow a plant to withstand or ward off a pathogen. The molecular responses of plants under pathogen attack and the underlying genetics have been extensively studied.
Hohmann, Pierre +3 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Complete Genome Resource for Pseudomonas sp. Strain WP18 Isolated from a Disease-Suppressive Soil
PhytoFrontiersBacterial strain WP18 was isolated in the Mississippi Delta from the rhizosphere of a healthy soybean plant growing in a charcoal rot disease patch, caused by the fungal pathogen Macrophomina phaseolina.
Emma Willis +3 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Research in Plant Disease, 2019 Plant viruses are among the important pathogens that cause severe crop losses. The most efficient method to control viral diseases is currently to use virus resistant crops.
Soo-Jung Han +3 more
doaj +1 more source
Prospects for durable resistance against an old soybean enemy: a four-decade journey from Rpp1 (Resistance to Phakopsora pachyrhizi) to Rpp7 [PDF]
, 2019 Open Access Journal; Published online: 1 July 2019Soybean rust (SBR), caused by Phakopsora spp., is a major global concern for soybean producers. SBR causing fungi are polycyclic and obligate biotrophs, rendering the study of their biology particularly ...
Bandyopadhyay, Ranajit +6 more
core +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
On the evolution of decoys in plant immune systems
, 2010 The Guard-Guardee model for plant immunity describes how resistance proteins (guards) in host cells monitor host target proteins (guardees) that are manipulated by pathogen effector proteins.
A Ashkenazi +12 more
core +1 more source