Results 81 to 90 of about 469,904 (306)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Characterization of Lr46, a gene conferring partial resistance to wheat leaf rust [PDF]

, 2001
Components of resistance conferred by the Lr46 gene, reported as causing "slow rusting" resistance to leaf rust in wheat, were studied and compared with the effects of Lr34 and genes for quantitative resistance in cv. Akabozu. Lr34 is a gene that confers
Martinez, F., Niks, R.E., Rubiales, D., Singh, R.P.   +3 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Breeding Crops for Enhanced Food Safety

Frontiers in Plant Science, 2020
An increasing global population demands a continuous supply of nutritious and safe food. Edible products can be contaminated with biological (e.g., bacteria, virus, protozoa), chemical (e.g., heavy metals, mycotoxins), and physical hazards during ...
Maeli Melotto, Maria T. Brandl, Cristián Jacob, Michele T. Jay-Russell, Shirley A. Micallef, Marilyn L. Warburton, Allen Van Deynze   +6 more
doaj   +1 more source

Host Plant Resistance in Brassicaceae against Aphids

, 2023
This chapter deals with brassica plants and their resistance to sucking pests—aphids. Brassica plants are known to synthesize a number of plant secondary metabolites which impart resistance to insect-pests and diseases. Aphids are known to feed primarily on sieve elements. The sieve elements in vascular bundles of angiosperms are important channels for
Neha Panwar, Sathya Thirumurugan, Sarwan Kumar   +2 more
openaire   +2 more sources

The coevolution of plants and viruses: Resistance and pathogenicity [PDF]

, 2010
Virus infection may damage the plant, and plant defenses are effective against viruses; thus, it is currently assumed that plants and viruses coevolve. However, and despite huge advances in understanding the mechanisms of pathogenicity and virulence in ...
Fraile Pérez, Aurora, Garcia-Arenal Rodriguez, Fernando   +1 more
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Diallel Analysis of Chili Pepper Resistance to Melon Aphid (Aphis Gossypii Glover) Infestation in Seedling Phase [PDF]

, 2018
Aphis gossypii Glover is one of important insect pest in Indonesia. Genetic analysis of resistance to A. gossypii is required in plant breeding program to obtain host-plant resistance cultivar. Diallel analysis was used to estimate genetic parameters for
Daryanto, A. (Ady), Hidayat, P. (Purnama), Maharijaya, A. (Awang), Syukur, M. (Muhamad)   +3 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source