Results 121 to 130 of about 7,269,938 (303)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Characteristics of a potyvirus associated with a mosaic-like disease of yellow oat-grass

Plant Protection Science, 2004
The properties of a new filamentous virus found on yellow oat-grass (suggested name Trisetum flavescens mosaic virus - TFMV) were compared with those of the two potyviruses Oat mosaic virus (OMV) and Oat necrotic mottle virus (ONMV).
Lenka Širlová, Josef Vacke, Milan Jokeš   +2 more
doaj   +1 more source

Community impacts of anthropogenic disturbance: natural enemies exploit multiple routes in pursuit of invading herbivore hosts [PDF]

, 2010
Background: Biological invasions provide a window on the process of community assembly. In particular, tracking natural enemy recruitment to invading hosts can reveal the relative roles of coevolution (including local adaptation) and ecological sorting ...
Hayward Alexander, Juli Pujade-Villar, Fuentes-Utrilla, Pablo, Nieves-Aldrey, Jose-Luis, Nieves-Aldrey José-Luis, Nieves-Aldrey, J. L., Stone Graham N, Graham N Stone, Hayward, Alexander, Tavakoli Majid, Melika George, Schoenrogge, Karsten, Pablo Fuentes-Utrilla, György Csóka, Csoka, Gyoergy, Melika, George, George Melika, Tavakoli, Majid, Pujade-Villar Juli, Nicholls James A, Schonrogge, Karsten, Csóka György, Alexander Hayward, José-Luis Nieves-Aldrey, Nicholls, James A., Schönrogge Karsten, Majid Tavakoli, Csoka, Gyorgy, James A Nicholls, Stone, Graham N., Fuentes-Utrilla Pablo, Karsten Schönrogge, Pujade-Villar, Juli, Stone, GN, Pujade-Villar, J, Hayward, A, Nicholls, JA, Schönrogge, K, Melika, G, Tavakoli, M, Nieves-Aldrey, J-L, Csóka, G, Fuentes-Utrilla, P   +42 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Modulation of pPS10 host range by plasmid-encoded RepA initiator protein

, 2003
We report here the isolation and analysis of novel repA host range mutants of pPS10, a plasmid originally found in Pseudomonas savastanoi. Upon hydroxylamine treatment, five plasmid mutants were selected for their establishment in Escherichia coli at 37 ...
Sanz, Juan, Maestro García-Donas, María Beatriz, Díaz-Orejas, Ramón, Fernández-Tresguerres, Elena   +3 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

A hypothesis to explain host species differences in resistance to multi-host parasites

Ideas in Ecology and Evolution, 2014
Here, we offer a novel hypothesis to explain why some host species evolve resistance, whereas other related species remain susceptible to a shared parasite species.
Mark R. Forbes, Julia J. Mlynarek
doaj