Results 101 to 110 of about 821,546 (355)

Biomarkers in ocular chronic graft versus host disease: tear cytokine- and chemokine-based predictive model. [PDF]

, 2016
Producción CientíficaPurpose: To develop a tear molecule level-based predictive model based on a panel of tear cytokines and their correlation with clinical features in ocular chronic graft versus host disease (cGVHD).
Caballero, Dolores, Calonge Cano, Margarita, Cocho, Lidia, Enríquez de Salamanca y Aladro, Amalia, Fernández Martínez, Itziar, García Vázquez, Carmen, González García, María Jesús, López Corral, Lucía, Martínez, Verónica, Stern, Michael E., Vázquez, Lourdes   +10 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The role of effectors in nonhost resistance to filamentous plant pathogens [PDF]

, 2014
In nature, most plants are resistant to a wide range of phytopathogens. However, mechanisms contributing to this so-called nonhost resistance (NHR) are poorly understood.
Aghnoum, Antonovics, Arabidopsis Genome Initiative, Baxter, Bolton, Brunner, Chen, de Jonge, de Jonge, de Wit, Dean, Dong, Elmore, Fan, Fradin, Fry, Gilroy, Gladieux, Haas, Hacquard, Jafary, Jeuken, Jones, Jupe, Jupe, Kang, Karasov, Kaschani, King, Kombrink, Lapin, Lee, Levesque, Lozano-Torres, Ma, Maekawa, Meyers, Mondragon-Palomino, Monosi, Morris, Mueller, Niks, Palloix, Pavan, Pedersen, Porter, Qutob, Raffaele, Raffaele, Raffaele, Rice Genome Project, Rouxel, Ruan, Saunders, Schulze-Lefert, Schweizer, Segretin, Shabab, Shan, Shen, Shindo, Spanu, Stam, Stassen, Stassen, Stirnweis, Stukenbrock, Stukenbrock, Stuttmann, Sweigard, Sørensen, Tian, Tosa, Uma, van Schie, Vega-Arreguín, Vogel, Wawra, Win, Wulff, Zellerhoff, Zhang, Zheng, Zipfel   +83 more
core   +5 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Attachment of Virus to Host Cell Surface upon Specific Binding to Membrane Receptors and Attachment Factors [PDF]

, 2023
Monika Chaudhary, Nagma Parveen
openalex   +1 more source

Odour perception in the codling moth Cydia pomonella L. [PDF]

, 2004
The codling moth, Cydia pomonella L. (Lepidoptera: Tortricidae) is a renowned pest in apple, pear and walnut orchards, and its activities are in large guided by volatile odours as sensory cues.
Ansebo, Lena
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Retro-inversion imparts antimycobacterial specificity to host defense peptides

Nature Communications
Antimicrobial host defense peptides are promising alternatives to resistance prone small molecule antibiotics. To overcome the poor physiologic stability of these therapeutic candidates it is common to prepare proteolytically resistant retro-inverso ...
Hugh D. Glossop, Gebremichal Gebretsadik, Sabiha Sultana, Diptomit Biswas, Nathan A. Schacht, Neela H. Yennawar, Muzafar Ahmad Rather, Anthony D. Baughn, Scott H. Medina   +8 more
doaj   +1 more source

Protein determinants of dissemination and host specificity of metallo-β-lactamases

Nature Communications, 2019
Metallo-β-lactamases (MBLs) confer resistance to carbapenem antibiotics. Here, López et al. show that the host range of MBLs depends on the efficiency of MBL signal peptide processing and secretion into outer membrane vesicles, which affects bacterial ...
Carolina López, Juan A. Ayala, Robert A. Bonomo, Lisandro J. González, Alejandro J. Vila   +4 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source