Results 91 to 100 of about 821,546 (355)
What determines host specificity in hyperspecialized plant parasitic nematodes?
BMC Genomics, 2019 Background In hyperspecialized parasites, the ability to grow on a particular host relies on specific virulence factors called effectors. These excreted proteins are involved in the molecular mechanisms of parasitism and distinguish virulent pathogens ...
Michael Sabeh +4 more
doaj +1 more source
A Thermodynamic Analysis of the Binding Specificity between Four Human PDZ Domains and Eight Host, Viral and Designed Ligands [PDF]
, 2021 Eva S. Cobos +4 more
openalex +1 more source
Combining experimental assays with epidemiological surveys to assess indicators of Plum pox virus epidemicity [PDF]
, 2013 The huge increase in sequence data those last decades has allowed defining better demarcation criteria for viral taxonomic assignments. For the epidemiologists, such demarcation based on molecular properties, especially at the strain level, is ...
Bonnot, François +6 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Host Specificity in Raiding Behavior of the Slave-Making Ant Polyergus Lucidus
Psyche: A Journal of Entomology, 1987 In the pine barrens of Suffolk County, New York, at least three species of Formica (subgenus Neoformica) are used as slaves by the obligatory slave-making ant Polyergus lucidus. In any single nest, however, only one slave species may be found.
Linda Goodloe +2 more
doaj +1 more source
Communications Biology, 2023 In host-symbiont systems, interspecific transmissions create opportunities for host switches, potentially leading to cophylogenetic incongruence. In contrast, conspecific transmissions often result in high host specificity and congruent cophylogenies. In
Luiz Gustavo A. Pedroso +8 more
doaj +1 more source
Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. [PDF]
, 2016 IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps.
Daugherty, Matthew D +3 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Cacti microbiome: interplay between habitat-filtering and host specificity
Frontiers in Microbiology, 2016 Cactaceae represents one of the most species-rich families of succulent plants native to arid and semi-arid ecosystems, yet the associations Cacti establish with microorganisms and the rules governing microbial community assembly remain poorly understood.
Citlali eFonseca-Garcia +11 more
doaj +1 more source