Results 71 to 80 of about 2,186,753 (294)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Temperature Alters Specificity in a Host–Parasite Interaction

Ecology and Evolution
The Red Queen Hypothesis proposes that genetic variation is maintained in populations through antagonistic coevolution of hosts and parasites. A major assumption of the Red Queen Hypothesis is tight genetic specificity for infection. However, it has been
Abbey Ramirez, Amanda Gibson
doaj   +1 more source

Host Specificity in Raiding Behavior of the Slave-Making Ant Polyergus Lucidus

Psyche: A Journal of Entomology, 1987
In the pine barrens of Suffolk County, New York, at least three species of Formica (subgenus Neoformica) are used as slaves by the obligatory slave-making ant Polyergus lucidus. In any single nest, however, only one slave species may be found.
Linda Goodloe, Raymond Sanwald, Howard Topoff   +2 more
doaj   +1 more source

Host sexual dimorphism and parasite adaptation [PDF]

, 2012
In species with separate sexes, parasite prevalence and disease expression is often different between males and females. This effect has mainly been attributed to sex differences in host traits, such as immune response.
Duneau, D., Ebert, Dieter, Dieter Ebert, David Duneau, Duneau David, Ebert Dieter   +5 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The Cacti microbiome: interplay between habitat-filtering and host specificity

Frontiers in Microbiology, 2016
Cactaceae represents one of the most species-rich families of succulent plants native to arid and semi-arid ecosystems, yet the associations Cacti establish with microorganisms and the rules governing microbial community assembly remain poorly understood.
Citlali eFonseca-Garcia, Devin eColeman-Derr, Devin eColeman-Derr, Devin eColeman-Derr, Etzel eGarrido, Etzel eGarrido, Axel eVisel, Axel eVisel, Axel eVisel, Susannah Green Tringe, Susannah Green Tringe, Laila Pamela Partida-Martinez   +11 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Retro-inversion imparts antimycobacterial specificity to host defense peptides

Nature Communications
Antimicrobial host defense peptides are promising alternatives to resistance prone small molecule antibiotics. To overcome the poor physiologic stability of these therapeutic candidates it is common to prepare proteolytically resistant retro-inverso ...
Hugh D. Glossop, Gebremichal Gebretsadik, Sabiha Sultana, Diptomit Biswas, Nathan A. Schacht, Neela H. Yennawar, Muzafar Ahmad Rather, Anthony D. Baughn, Scott H. Medina   +8 more
doaj   +1 more source

Host specificity, but not high-temperature tolerance, is associated with recent outbreaks of Verticillium dahliae in chrysanthemum in the Netherlands [PDF]

, 2008
Two hypotheses which might explain a recent increase in the incidence of verticillium wilt of chrysanthemums in glasshouses in the Netherlands were investigated, viz whether selection for increased resistance to elevated temperatures has occurred due to ...
Goud, J. C. (Jan-Kees C.), Termorshuizen, A.J., Goud, J.C., Barbara, D.J., Termorshuizen, A. J., Barbara, Dez J., Ispahani, S. K., Morton, A., Ispahani, S.K.   +8 more
core   +1 more source