Results 51 to 60 of about 1,982,323 (298)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Host sexual dimorphism and parasite adaptation [PDF]

, 2012
In species with separate sexes, parasite prevalence and disease expression is often different between males and females. This effect has mainly been attributed to sex differences in host traits, such as immune response.
Duneau, D., Ebert, Dieter, Dieter Ebert, David Duneau, Duneau David, Ebert Dieter   +5 more
core   +2 more sources

Heterogeneities in infection outcomes across species: sex and tissue differences in virus susceptibility

Peer Community Journal, 2023
Species vary in their susceptibility to pathogens, and this can alter the ability of a pathogen to infect a novel host. However, many factors can generate heterogeneity in infection outcomes, obscuring our ability to understand pathogen emergence.
Roberts, Katherine E, Longdon, Ben
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection [PDF]

, 2010
The postgenomic era has revolutionized approaches to defining host-pathogen interactions and the investigation of the influence of genetic variation in either protagonist upon infection outcome.
C. Michael R. Turner, Chan, Chi N, Tait, Andy, Andy Tait, Morrison, L.J., McLellan, Sarah, Turner, C Michael R, Sweeney, Lindsay, Chan, C.N., Liam J. Morrison, Annette MacLeod, Sweeney, L., Turner, C.M.R., Morrison, Liam J; id_orcid, Lindsay Sweeney, Chi N. Chan, Tait, A., Sarah McLellan, MacLeod, A., McLellan, S., MacLeod, Annette   +20 more
core   +1 more source

The Host Tissue Repair Vulnerability Index (HTRVI): A Composite Biomarker for Predicting Osteoradionecrosis in Locally Advanced Nasopharyngeal Carcinoma

Medical Sciences
Background: Osteoradionecrosis of the jaw (ORNJ) remains a major late complication of head and neck radiotherapy, and risk assessment relies mainly on clinical and dosimetric factors.
Efsun Somay, Erkan Topkan, Sibel Bascil, Ugur Selek   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria [PDF]

, 2009
Background Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control.
Thor G Theander, Troye-Blomberg, Marita,, Marita Troye-Blomberg, ElGhazali, Gehad, ElGhazali Gehad, Janardan P Pandey, Giha, Hayder A., Pandey, Janardan P, Giha Hayder A, Iriemenam, Nnaemeka C., Nasr, Amre, Gehad ElGhazali, David Arnot, Giha, Hayder A, Nasr, Amre,, Troye-Blomberg, Marita, Theander, Thor G., Pandey, Janardan P., Berzins, Klavs, Berzins Klavs, Berzins, Klavs,, Hayder A Giha, Nnaemeka C Iriemenam, Theander, Thor G, Theander Thor G, Iriemenam, Nnaemeka C, Troye-Blomberg Marita, Nasr Amre, Klavs Berzins, Iriemenam Nnaemeka C, Arnot, David, Amre Nasr, Arnot David, Pandey Janardan P, Iriemenam, Nnaemeka C.,   +34 more
core   +1 more source

The host phylogeny determines viral infectivity and replication across Staphylococcus host species.

PLoS Pathogens, 2023
Virus host shifts, where a virus transmits to and infects a novel host species, are a major source of emerging infectious disease. Genetic similarity between eukaryotic host species has been shown to be an important determinant of the outcome of virus ...
Sarah K Walsh, Ryan M Imrie, Marta Matuszewska, Gavin K Paterson, Lucy A Weinert, Jarrod D Hadfield, Angus Buckling, Ben Longdon   +7 more
doaj   +1 more source

Host Susceptibility to African Trypanosomiasis: Trypanotolerance

, 1982
Publisher Summary The exploitation of genetic resistance to disease is an important consideration in livestock development programs, where conventional disease control measures are not effective or are too costly. Such an approach may be directly applicable to African animal trypanosomiasis.
Murray, M., Morrison, W. Ivan, Whitelaw, D.D.   +2 more
openaire   +3 more sources