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Hot-melt extrusion of sugar-starch-pellets
International Journal of Pharmaceutics, 2015Sugar-starch-pellets (syn. sugar spheres) are usually manufactured through fluidized bed granulation or wet extrusion techniques. This paper introduces hot-melt extrusion (HME) as an alternative method to manufacture sugar-starch-pellets. A twin-screw extruder coupled with a Leistritz Micro Pelletizer (LMP) cutting machine was utilized for the ...
Chi-Wah, Yeung, Hubert, Rein
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Hot-melt Extrusion Technology and Pharmaceutical Application
Therapeutic Delivery, 2012The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to its proven ability to efficiently manufacture novel products. The process has been utilized readily in the plastics industry for over a century and has been used to manufacture medical devices for several decades.
Wilson, M. +3 more
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Pharmaceutical Applications of Hot-Melt Extrusion: Part II
Drug Development and Industrial Pharmacy, 2007Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare ...
Michael A, Repka +7 more
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Hot Melt Extrusion Technique-A Review
Research Journal of Science and Technology, 2016Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and ...
Bhushan A. Bhairav +2 more
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Hot-melt extrusion – basic principles and pharmaceutical applications
Drug Development and Industrial Pharmacy, 2014Originally adapted from the plastics industry, the use of hot-melt extrusion has gained favor in drug delivery applications both in academia and the pharmaceutical industry. Several commercial products made by hot-melt extrusion have been approved by the FDA, demonstrating its commercial feasibility for pharmaceutical processing.
Bo, Lang +2 more
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Residence time modeling of hot melt extrusion processes
European Journal of Pharmaceutics and Biopharmaceutics, 2013The hot melt extrusion process is a widespread technique to mix viscous melts. The residence time of material in the process frequently determines the product properties. An experimental setup and a corresponding mathematical model were developed to evaluate residence time and residence time distribution in twin screw extrusion processes. The extrusion
Elena, Reitz +3 more
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Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2012
Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism.
Salandová, Jana, Rabišková, Miloslava
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Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism.
Salandová, Jana, Rabišková, Miloslava
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Distributed parameter modeling of hot-melt extrusion
2016 International Conference on System Science and Engineering (ICSSE), 2016Hot-melt extrusion is increasingly used in industry for product forming. In this context, mathematical modeling plays an important role to determine the best process operating conditions, but also to possibly develop software sensors or controllers. This study proposes a distributed parameter model consisting in partial differential equations derived ...
Jonathan Grimard +2 more
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Hot-Melt Extrusion Technique: A Review
2004Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and ...
Chokshi, R, Zia, H
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Preparation of starch-based pellets by hot-melt extrusion
European Journal of Pharmaceutics and Biopharmaceutics, 2011Spherical starch pellets were directly and continuously produced using hot-melt extrusion and die-face pelletisation. In contrast to conventional pelletisation procedures, a discontinuous spheronisation step can be dropped. Pellets were produced based on four different starches (corn starch, pea starch, potato starch and waxy corn starch), four ...
Sebastian, Bialleck, Hubert, Rein
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