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Preparation of starch-based pellets by hot-melt extrusion
European Journal of Pharmaceutics and Biopharmaceutics, 2011Spherical starch pellets were directly and continuously produced using hot-melt extrusion and die-face pelletisation. In contrast to conventional pelletisation procedures, a discontinuous spheronisation step can be dropped. Pellets were produced based on four different starches (corn starch, pea starch, potato starch and waxy corn starch), four ...
Sebastian, Bialleck, Hubert, Rein
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Hot-melt extrusion – basic principles and pharmaceutical applications
Drug Development and Industrial Pharmacy, 2014Originally adapted from the plastics industry, the use of hot-melt extrusion has gained favor in drug delivery applications both in academia and the pharmaceutical industry. Several commercial products made by hot-melt extrusion have been approved by the FDA, demonstrating its commercial feasibility for pharmaceutical processing.
Bo, Lang +2 more
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Hot-Melt Extrusion Technique: A Review
2004Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and ...
Chokshi, R, Zia, H
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Distributed parameter modeling of hot-melt extrusion
2016 International Conference on System Science and Engineering (ICSSE), 2016Hot-melt extrusion is increasingly used in industry for product forming. In this context, mathematical modeling plays an important role to determine the best process operating conditions, but also to possibly develop software sensors or controllers. This study proposes a distributed parameter model consisting in partial differential equations derived ...
Grimard, Jonathan +2 more
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Application of rheology to hot melt extrusion: Theory and practice
International Journal of PharmaceuticsHot melt extrusion (HME) has become a key manufacturing method in the pharmaceutical industry for developing novel drug delivery systems, due to its solvent-free nature, ease of operation, and ability to achieve one-step molding and continuous processing.
Yisen, Wang +7 more
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A novel design for hot-melt extrusion pelletizers
Chemical Engineering Science, 2010Abstract In this work we investigated a novel die design for the scale-up of hot melt extrusion (HME) devices for direct pelletization of pharmaceutics. Therefore we analyzed the temperature distribution in a lab- and production-scale die as well as melt flow through the die.
Stefan Radl +2 more
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Hot Melt Extrusion of Acrylic Films
Pharmaceutical Research, 1996C, Aitken-Nichol +2 more
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Basics of Compounding: Hot Melt Extrusion.
International journal of pharmaceutical compounding, 2018Hot Melt Extrusion, a production process that has been around for quite some time, has the ability to produce innovative compounds not previously achievable with conventional methods. However, many variables need to be considered prior to production.
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