Results 101 to 110 of about 32,079 (250)
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
C-19 and Hot, Wide Star Streams
The Astrophysical JournalThe C-19 star stream has the abundance characteristics of an unusually metal-poor globular cluster but kinematically is uncharacteristically hot and wide for a cluster stream, having a line-of-sight velocity dispersion of 7 ± 2 km s ^−1 and a 1 σ width
Raymond G. Carlberg +7 more
doaj +1 more source
Cosmology: What One Needs to Know
Zygon, 2000 Cosmology, the study of the universe, has a past, which is reviewed here. The standard model—the Big Bang, or the hot, dense early universe that is still expanding—is based on observations that are basically consistent but which require additional input
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G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Hydro-Gravitational Dynamics of Planets and Dark Energy
Journal of Applied Fluid Mechanics, 2009 Self gravitational fluid mechanical methods termed hydro-gravitational-dynamics (HGD) predict plasma fragmentation 0.03 Myr after the turbulent big bang to form protosuperclustervoids, turbulent protosuperclusters, and protogalaxies at the 0.3 Myr ...
Carl H. Gibson, R.E, Schild
doaj
Phase Diagrams and Piezoelectric Properties of Wurtzite Al1−x−yScxGdyN Heterostructural Alloys
Advanced Science, EarlyView.This study demonstrates ferroelectricity and piezoelectric properties improvement of quaternary wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films, guided by density functional theory calculations. Wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films have a high optical bandgap, enhanced piezoelectric ...
Julia L. Martin +11 more
wiley +1 more source
Constraints on massive neutrinos as hot dark matter
Nuclear Physics B - Proceedings Supplements, 1996 This article highlights three astronomical observations that can constrain the masses of neutrinos as hot dark matter: high-redshift damped Lyα systems, the cosmic microwave background anisotropy, and gravitational lenses. Theoretical predictions and current constraints are summarized.
openaire +1 more source
Advanced Science, EarlyView.This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina +6 more
wiley +1 more source
Refracted Gravity Solutions from Small to Large Scales
AstronomyIf visible matter alone is present in the Universe, general relativity (GR) and its Newtonian weak field limit (WFL) cannot explain several pieces of evidence, from the largest to the smallest scales.
Valentina Cesare
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Decay-Produced Neutrino Hot Dark Matter
Physical Review Letters, 1998 We investigate different types of neutrino hot dark matter with respect to structure formation and anisotropies in the cosmic microwave background radiation (CMBR). The possibility of neutrino hot dark matter produced through the decay of a heavier neutrino by the process nu_H -> nu_L + phi, where phi is a scalar particle, is discussed in detail ...
openaire +2 more sources