Results 101 to 110 of about 718,142 (310)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Stress coping strategies — novel markers in the diagnosis of masked hypertension in young people

Кардиоваскулярная терапия и профилактика
Aim. To establish the prevalence and markers of masked hypertension (HTN) in apparently healthy young people.Material and methods. The cross-sectional study included young people (20-30 years old) with health group I or II, with clinical blood pressure ...
A. O. Shevchenko, Yu. M. Yufereva, Yu. A. Gerasimova, R. G. Timofeev, R. A. Faradzhov   +4 more
doaj   +1 more source

Mutant loxP vectors for selectable marker recycle and conditional knock-outs [PDF]

, 2001
BACKGROUND: Gene disruption by targeted integration of transfected constructs becomes increasingly popular for studies of gene function. The chicken B cell line DT40 has been widely used as a model for gene knock-outs due to its high targeted integration
Arakawa, Hiroshi, Buerstedde, Jean-Marie, Lodygin, Dimitry   +2 more
core   +3 more sources

Effects of total knee arthroplasty on markers of muscle damage two hours after surgery (1102.33)

The FASEB Journal, 2014
Total knee arthroplasty (TKA) results in rapid muscle atrophy, decreased strength, and functional mobility limitations. Our prior reports on the acute effects of ischemia and reperfusion during TKA suggests decreased protein synthesis, increased protein degradation, and activation of the endoplasmic reticulum (ER) stress response in skeletal muscle ...
Austin Hocker, Brian Jewett, Steven Shah, Brick Lantz, Hans Dreyer   +4 more
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Biomarkers Beyond the Natriuretic Peptides for Chronic Heart Failure: Galectin-3 and Soluble ST2. [PDF]

, 2012
B-type natriuretic peptide (BNP) and NT-proBNP are widely used plasma biomarkers for the diagnosis of acute decompensated heart failure and prognosis for future cardiac disease.
Wu, Alan HB
core   +1 more source

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-antibodies [PDF]

, 2016
Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and ...
Contrufo, Geraldine, Espasandin, Yesica Romina, García, Alejandro Jorge, Glembotsky, Ana Claudia, Goette, Nora Paula, Grodzielski, Matías, Heller, Paula Graciela, Lev, Paola Roxana, Marta, Rosana Fernanda, Molinas, Felisa Concepción, Pierdominici, Marta S., Riveros, Dardo Alberto   +11 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Modelling obstructive sleep apnea susceptibility using non-invasive inflammatory biomarkers

Egyptian Journal of Chest Disease and Tuberculosis, 2017
Background: Obstructive sleep apnea (OSA) is considered systemic inflammatory disease but airway and systemic inflammatory markers roles in OSA prediction are not widely used in sleep clinics.
Lucy Abd El Mabood Suliman, Nesreen Elsayed Morsy, Ahmed Hassan El-Sebaie, Nisreen M. Abo-Emaaty Omar, Amal Fathy   +4 more
doaj   +1 more source

Relationship between the peroxidation of leukocytes index ratio and the improvement of postprandial metabolic stress by a functional food [PDF]

, 2015
For the first time, we investigated the relationship between postprandial dysmetabolism and the Peroxidation of Leukocytes Index Ratio (PLIR), a test that measures the resistance of leukocytes to exogenous oxidative stress and their functional capacity ...
Longhitano, Yaroslava, Manafikhi, Husseen, Palmery, Maura, Peluso, Ilaria, Reggi, Raffaella, Zanza, Christian   +5 more
core   +4 more sources