Results 61 to 70 of about 2,843,314 (312)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Integration of Quality Function Deployment and TRIZ Methodologies to Design a Sanitary Part [PDF]

International Journal of Industrial Engineering and Production Research
A typical definition of New Product Development is a series of actions that begins with the identification of a market opportunity and concludes with the creation, marketing, and delivery of a product.
Dino Caesaron, Farell Ardani, Vidhea Nurhadi, Yusuf Yekti   +3 more
doaj  

PENYUSUNAN HOUSE OF QUALITY MENGGUNAKAN METODE QUALITY FUNCTION DEPLOYMENT

Jurnal Mitra Teknik Industri, 2023
PT. XYZ adalah sebuah perusahaan yang memproduksi rak industri. Terdapat beberapa keluhan seperti adanya rak penyok, rak cat terkelupas, tinggi yang tidak rata, las tidak penuh dan tidak rapi, ataupun hal lainnya yang menyebabkan pelanggan tidak puas.
null Yvette Josephine, null Ahmad, null Andres   +2 more
openaire   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

IMPLEMENTASI METODE QUALITY FUNCTION DEPLOYMENT (QFD) GUNA MENINGKATKAN KUALITAS KAIN BATIK TULIS

Jurnal Ilmiah Teknik Industri, 2006
Pemilihan dan pengoptimalan suatu metode yang lebih baik untuk meningkatkan mutu suatu produk atau jasa yang dihasilkan sangat diperlukan oleh perusahaan dewasa ini.
Jono Jono
doaj   +1 more source

Expected Home Ownership and Real Wealth Accumulation of Youth [PDF]

This paper describes the real wealth accumulation of American youth and relates this behavior to variations in real constant-quality house prices in their localities of residence.
Donald R. Haurin, Patric H. Hendershott, Susan M. Wachter   +2 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

House prices and the quality of public schools: what are we buying? [PDF]

Do house prices reflect the quality of the local public schools? To what extent do school district policies determine how well students perform? How do such factors as neighborhood, family, and peers affect school quality and house prices?
Theodore M. Crone
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source