Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
House of Marketing Quality Using the House of Quality to Develop Marketing Strategies
The paper presents a Model for Customer Oriented Marketing Strategies, using the House of Quality Approach. The model is presented with an example of Spinning Machinery Marketing.
Bayram Aslan, Helmut H. Hergeth
openaire +2 more sources
Ranking of Urban Areas in Terms of Quantitative and Qualitative Housing Indicators (Case Study: 22 Regions of Arak City) [PDF]
Aim: This research attempts to rank the 22 districts of Arak based on quantitative and qualitative housing indicators and to identify the spatial distribution pattern of these indicators at the city level. Material & Method: Subsequently, using Shannon's
Hossein Hataminejad +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Semi-open urban blocks and convertible apartments: A-4 residential buildings in Novi Sad, awarded the Borba prize for architecture [PDF]
The article examines the architectural and urban characteristics of the residential building (type A-4), which was designed during the implementation of the Novo Naselje urban project in Novi Sad in the 1970s. The authors were architects Slavko Županski,
Antešević Nebojša, Gubić Ilija
doaj +1 more source
An Analysis of spatial inequalities of Housing quality in middle textures neighboods of zanjan city [PDF]
Housing as one of the basic human needs a significant impact on the health and improve the quality of life of individuals. The quality of housing as one of the main foundations of a comprehensive program and a necessary tool for expressing the various ...
Mohsen Ahadnejad +3 more
doaj
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Egypt’s thriving marble industry produces extensive waste marble powder (WMP) amounts. Recycling plentiful waste safely and effectively is a key national concern, as improper disposal poses a serious threat to the environment.
Alaa M. Rashad +3 more
doaj +1 more source
Les multiples facettes des inégalités écologiques
The notion of ecological inequalities is understood in very different ways depending on different cultural contexts. In the United States, where it has first developed, its only meaning is in an action perspective.
Lionel Charles +5 more
doaj +1 more source
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source

