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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Scientific ReportsAs is well established, slag precursor offers promising performance characteristics; however, its origin as an industrial byproduct leads to variability in both mineralogical and chemical composition.
Alaa M. Rashad +3 more
doaj +1 more source
Les multiples facettes des inégalités écologiques
Développement Durable et Territoires, 2007 The notion of ecological inequalities is understood in very different ways depending on different cultural contexts. In the United States, where it has first developed, its only meaning is in an action perspective.
Lionel Charles +5 more
doaj +1 more source
An Analysis of spatial inequalities of Housing quality in middle textures neighboods of zanjan city [PDF]
تحقیقات کاربردی علوم جغرافیایی, 2021 Housing as one of the basic human needs a significant impact on the health and improve the quality of life of individuals. The quality of housing as one of the main foundations of a comprehensive program and a necessary tool for expressing the various ...
Mohsen Ahadnejad +3 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 2013 January-December 2003; application/pdf; Annual cumulation of 2013 issuesNominations Sought For Outstanding Achievements In Affordable Housing National Campaign Launched to Highlight Fair Housing Month Motive Power Place Offers Affordable Housing for ...
Kansas Housing Resources Corporation.
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
, 2020 Kansas Housing awards $2.3 million for rural housing development -- In search of a fresh start, and dignity -- Alissa Ice named Director of Housing Development -- Addressing the Need: 2019 Annual Report -- Kansas Housing awards $150,000 to support ...
Kansas Housing Resources Corporation.
core
An evaluation tool for design quality: PFI sheltered housing [PDF]
, 2013 The complex procurement process entailed by the private finance initiative (PFI) means that clients need new capacities to manage their relationships with bidders and to assess project proposals if the desired level of design quality is to be achieved ...
Giddings, Bob +3 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source