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Genomics of the HOX gene cluster
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2002The Hox family of homeobox genes encode transcription factors that control different aspects of metazoan development. They appear clustered in the genomes of those animals in which their relative positions have been mapped. Although clustering is assumed to be a general property of Hox genes in all bilaterians, just a few species have been studied in ...
Pedro, Martinez, Chris T, Amemiya
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Seminars in Reproductive Medicine, 2007
Implantation is a complex event requiring synchronization between a developing embryo and receptive endometrium. This process is governed by molecular mechanism mediated by homeobox (Hox) genes, which encode transcription factors. These factors guide embryologic development as well as regulate differential gene expression within the endometrium with ...
Danielle, Vitiello +2 more
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Implantation is a complex event requiring synchronization between a developing embryo and receptive endometrium. This process is governed by molecular mechanism mediated by homeobox (Hox) genes, which encode transcription factors. These factors guide embryologic development as well as regulate differential gene expression within the endometrium with ...
Danielle, Vitiello +2 more
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Annual Review of Genetics, 1994
control of metazoan organisms. In this article, we review the distribution of this gene family in selected species of the major phyla of metazoans, and from these data evaluate the usefulness of this system for establishing phyletic affinities, and the potential of using developmental genes as a means of ob taining insights into evolutionary mecha ...
F H, Ruddle +5 more
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control of metazoan organisms. In this article, we review the distribution of this gene family in selected species of the major phyla of metazoans, and from these data evaluate the usefulness of this system for establishing phyletic affinities, and the potential of using developmental genes as a means of ob taining insights into evolutionary mecha ...
F H, Ruddle +5 more
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Hox genes and kidney patterning
Current Opinion in Nephrology and Hypertension, 2003Hox gene activity is essential for proper organization or pattern of the vertebrate body plan and is necessary for organogenesis. Sequence conservation within this family of genes is high yet they are involved in very diverse developmental processes.
Larry T, Patterson, S Steven, Potter
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Hox genes regulation in vertebrates
Developmental Dynamics, 2013Hox genes encode transcription factors defining cellular identities along the major and secondary body axes. Their coordinated expression in both space and time is critical for embryonic patterning. Accordingly, Hox genes transcription is tightly controlled at multiple levels, and involves an intricate combination of local and long‐range cis‐regulatory
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Hox genes, clusters and collinearity
The International Journal of Developmental Biology, 2018This year marks the 40th anniversary of the discovery by Ed Lewis of the property of collinearity in the bithorax gene complex in Drosophila. This landmark work illustrated the need to understand regulatory mechanisms that coordinate expression of homeotic gene clusters.
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Invasion & metastasis, 1995
Knowledge about transcription factors is crucial for understanding the molecular basis of neoplasia. Homeobox-containing genes are a family of transcription factors mostly involved in normal development. Class I human homeobox-containing genes (HOX genes) are organized in four clusters on different chromosomes.
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Knowledge about transcription factors is crucial for understanding the molecular basis of neoplasia. Homeobox-containing genes are a family of transcription factors mostly involved in normal development. Class I human homeobox-containing genes (HOX genes) are organized in four clusters on different chromosomes.
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Modulating Hox Gene Functions During Animal Body Patterning
Nature Reviews Genetics, 2005William McGinnis, Joseph C Pearson
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