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Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man +7 more
wiley +1 more source

Drivers of disease emergence and spread: Is wildlife to blame? [PDF]

, 2014
The global focus on wildlife as a major contributor to emerging pathogens and infectious diseases (EIDs) in humans and domestic animals is not based on field, experimental or dedicated research, but mostly on limited surveys of literature, opinion and ...
Kock, R A
core +2 more sources

Antiviral therapy for HPAI and reported oseltamivir resistance in Canada

Journal of the Association of Medical Microbiology and Infectious Disease Canada
Mubareka, Samira +6 more
openaire +3 more sources

Emergence, spread, and impact of high‐pathogenicity avian influenza H5 in wild birds and mammals of South America and Antarctica

Conservation Biology, Volume 40, Issue 1, February 2026.
Abstract The currently circulating high‐pathogenicity avian influenza (HPAI) virus of the subtype H5 causes variable illness and death in wild and domestic birds and mammals, as well as in humans. This virus evolved from the Goose/Guangdong lineage of the HPAI H5 virus, which emerged in commercial poultry in China in 1996, spilled over into wild birds,
Thijs Kuiken +9 more
wiley +1 more source

Clustering broiler farmers based on their behavioural differences towards biosecurity to prevent highly pathogenic avian influenza

One Health
Highly pathogenic avian influenza (HPAI) is an important zoonotic disease. The study aims to identify farmer behaviour types to inform the design of behaviour change programmes for mitigating the transmission of HPAI.
Hai-ni Pao +6 more
doaj +1 more source

Mission to Indonesia to participate to the 1st Indonesia- France Seminar in Medicine & Public Health and investigate potential collaborations on animal health : 2nd - 9th of November 2012 [PDF]

, 2012
Emerging and zoonotic infectious diseases are a major issue in Indonesia. The objective of this mission, funded by the Institut Français d'Indonésie (IFI), was to identify potential subjects of collaboration between CIRAD, Pasteur Institute, and ...
Bourhy, Hervé, Gaidet, Nicolas, Molia, Sophie +2 more
core

Vulnerability of marine megafauna to global at‐sea anthropogenic threats

Conservation Biology, Volume 40, Issue 1, February 2026.
Abstract Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened ...
Michelle VanCompernolle +309 more
wiley +1 more source

First Case of Highly Pathogenic Avian Influenza H5N1 in Montenegro

Acta Veterinaria
Avian influenza, commonly known as bird flu, is a highly infectious viral disease that affects birds, including wild water birds and poultry. The emergence and spread of highly pathogenic avian influenza (HPAI) strains, such as H5N1, have raised concerns
Adzic Bojan +4 more
doaj +1 more source

Highly pathogenic or low pathogenic avian influenza virus subtype H7N1 infection in chicken lungs: small differences in general acute responses

Veterinary Research, 2011
Avian influenza virus can be divided into two groups, highly pathogenic avian influenza virus (HPAI) and low pathogenic avian influenza virus (LPAI) based on their difference in virulence. To investigate if the difference in clinical outcome between LPAI
Rebel Johanna MJ +5 more
doaj +1 more source

Combined H5ND inactivated vaccine protects chickens against challenge by different clades of highly pathogenic avian influenza viruses subtype H5 and virulent Newcastle disease virus [PDF]

Veterinary World, 2019
Aim: The aim of the current study was to evaluate the efficacy of a trivalent-inactivated oil-emulsion vaccine against challenge by different clades highly pathogenic avian influenza (HPAI) viruses including HPAI-H5N8 and the virulent genotype VII ...
Ahmed Ali +7 more
doaj +1 more source

biology
virology
influenza a virus subtype h5n1

virus
medicine
highly pathogenic

avian influenza
geography
gene