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Comparison of the Immunogenicity and Efficacy of a Replication‐Defective Vaccinia Virus Expressing Antigens of Human Parainfluenza Virus Type 3 (HPIV3) with Those of a Live Attenuated HPIV3 Vaccine Candidate in Rhesus Monkeys Passively Immunized with PIV3 Antibodies [PDF]

Journal of Infectious Diseases, 1999
Two parainfluenza virus type 3 (PIV3) vaccine candidates-cp45, a live attenuated derivative of the JS wild type (wt), and a replication-defective vaccinia virus recombinant expressing the hemagglutinin-neuraminidase or fusion glycoprotein of human PIV3 (modified vaccinia virus Ankara [MVA]/PIV3 recombinants)-were evaluated in rhesus monkeys to ...
William R Elkins, Linda S Wyatt, Bernard Moss   +2 more
exaly   +3 more sources

Human parainfluenza virus type 3 (HPIV3) induces production of IFNγ and RANTES in human nasal epithelial cells (HNECs) [PDF]

Journal of Inflammation, 2015
Human parainfluenza virus type 3 (HPIV3), while infecting lower airway epithelial cells induces pneumonia and bronchiolitis in infants and children, and may lead to asthma exacerbations in children and adults. Respiratory viruses invading the airway epithelium activate innate immune response and induce inflammatory cytokine release contributing to the ...
Anna Lewandowska-Polak, Małgorzata Brauncajs, Edyta Paradowska   +2 more
exaly   +3 more sources

Human Parainfluenza Viruses hPIV1 and hPIV3 Bind Oligosaccharides with α2-3-Linked Sialic Acids That Are Distinct from Those Bound by H5 Avian Influenza Virus Hemagglutinin [PDF]

Journal of Virology, 2007
ABSTRACTWe investigated the binding of human parainfluenza virus types 1 and 3 (hPIV1 and hPIV3, respectively) to the glycan array of the Consortium for Functional Glycomics and binding and their release from erythrocytes under conditions where neuraminidase is inactive or active. hPIV1 and hPIV3 bind modifications of Neu5Acα2-3Galβ1-4GlcNAc, including
David F Smith, Richard D Cummings, Gillian M Air   +2 more
exaly   +3 more sources

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Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN)

Antiviral Research, 2015
The human parainfluenza virus type 3 (hPIV3) hemagglutinin-neuraminidase (HN) has opposing functions of binding sialic acid receptors and cleaving them, facilitating virus release. The crystal structure of hPIV3 HN complexed with the substrate analogue difluorosialic acid (DFSA) revealed that catalysis by HN involves the formation of a covalently ...
VÍCTOR A Streltsov, Jennifer L Mckimm-Breschkin   +1 more
exaly   +3 more sources

Safety and infectivity of two doses of live-attenuated recombinant cold-passaged human parainfluenza type 3 virus vaccine rHPIV3cp45 in HPIV3-seronegative young children

Vaccine, 2013
Human parainfluenza virus type 3 (HPIV3) is a common cause of upper and lower respiratory tract illness in infants and young children. Live-attenuated cold-adapted HPIV3 vaccines have been evaluated in infants but a suitable interval for administration of a second dose of vaccine has not been defined.HPIV3-seronegative children between the ages of 6 ...
Janet A Englund, Ruth A Karron, Ann Melvin   +2 more
exaly   +3 more sources

MHC Class II Gene Expression Is Not Induced in HPIV3-Infected Respiratory Epithelial Cells

Immunologic Research, 2004
The major histocompatibility complex (MHC) class II transactivator (CIITA) typically is required for both constitutive and inducible expression of MHC class II genes. However, transcription of class II MHC genes has been observed in specific cell types (e.g., thymic epithelial cells) in CIITA-deficient mice as well as in specific situations (e.g ...
Michael, Radosevich, Santa Jeremy, Ono
openaire   +2 more sources

Deletion of the D domain of the human parainfluenza virus type 3 (HPIV3) PD protein results in decreased viral RNA synthesis and beta interferon (IFN-β) expression

Virus Genes, 2013
The human parainfluenza virus type 3 (HPIV3) phosphoprotein (P) gene is unusual as it contains an editing site where nontemplated ribonucleotide residues can be inserted. This RNA editing can lead to the expression of the viral P, PD, putative W, and theoretical V protein from a single gene. Although the HPIV3 PD protein has been detected, its function
Joseph K -K Li, John D Morrey, Dale L Barnard   +2 more
exaly   +3 more sources

Detection of IL-17 Genetic Polymorphisms in Sample of Iraqi Patients with parainfluenza virus type 3 (HPIV3)

Indian Journal of Forensic Medicine & Toxicology, 2019
One of the acute respiratory illness is precipitated by human parainfluenza viruses (PIVs) that infect the immunocompromised patients particularly in children and the elderly. A common cause of bronchiolitis and pneumonia is PIV1 and whereas is the one frequent causes of upper respiratory tract illness and croup is PIV2.
Noor Hameed Alkharsan, Siham Jasim Al-kaabi   +1 more
openaire   +1 more source

Analysis of the mutations in the active site of the RNA-dependent RNA polymerase of human parainfluenza virus type 3 (HPIV3).

Gene expression, 2002
The large protein (L) of the human parainfluenza virus type 3 (HPIV3) is the functional RNA-dependent RNA polymerase, which possesses highly conserved residues QGDNQ located within motif C of domain III comprising the putative polymerase active site. We have characterized the role of the QGDNQ residues as well as the residues flanking this region in ...
Achut G, Malur, Neera K, Gupta, P, De Bishnu, Amiya K, Banerjee   +3 more
openaire   +1 more source

Construction expressing vector the hemagglutinin protein of Human Parainfluenza Virus Type 3 (HPIV3)

Journal of Clinical Virology, 2015
D. Behzadpour, Seyed Dawood Mousavi Nasab   +1 more
openaire   +1 more source