Results 31 to 40 of about 1,009,434 (343)
One pot ‘click’ reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition [PDF]
Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.
Campbell-Verduyn, Lachlan S.,+6 more
core +2 more sources
Developing an Analytical Method for Separating and Quantifying RNA Generated in In Vitro Transcription Reactions [PDF]
The generation of run-off transcripts from in vitro transcription reactions is a useful technique in the study of transcription regulation. There are currently limited ways in which these run-off transcripts can be analyzed, and few that are truly ...
Wienkers, Henry
core +1 more source
Two-step separation of nostotrebin 6 from cultivated soil cyanobacterium (Nostoc sp.) by high performance countercurrent chromatography [PDF]
High performance countercurrent chromatography (HPCCC) was successfully applied for the separation of nostotrebin 6 from cultivated soil cyanobacteria in a two-step operation.
Berthod+13 more
core +2 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
Aim. Study the composition of plant extracts using high-performance liquid chromatography (HPLC) and evaluation of their antimicrobial effect against Vibrio cholerae El Tor. Materials and methods.
O. V. Markina+6 more
doaj +1 more source
Allelopathic effect of the Cladonia verticillaris lichen extracts and fumarprotocetraric acid on the early growth of germinated seedlings in Allium cepa L. [PDF]
The allelopathic activity of the different type of Cladonia verticillaris lichen extracts and fumarprotocetraric acid on the early growth of A. cepa (IPA 6) germinated seedlings depends on their chemical composition and concentration, respectively.
Vicente, Carlos+2 more
core
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi+12 more
wiley +1 more source
The aim of this study was to investigate a novel means of treating piglet diarrhoea caused by enterotoxigenic Escherichia coli (ETEC) strain K88 using traditional Chinese medicine (TCM) fermented by selected probiotic strains.
Wei Gu+6 more
doaj +1 more source
جداسازی و شناسایی میکسوباکتر تولیدکنندۀ Myxothiazol و Althiomycin از خاک ایران [PDF]
میکسوباکترها در دستۀ باکتریهای خاک قرار میگیرند که حرکت لغزشی دارند و اجسام زایشی ایجاد میکنند. جدایه میکسوباکتریایی 118 از خاک منطقۀ کوهرنگ چهارمحال و بختیاری جداسازی شد و فعالیت زیستی آن علیه پاتوژنهای مختلف انسانی به روش رقتسازی در میکروپلیت ...
اعظم مرادی+3 more
doaj +1 more source
I detta projektarbete skulle tre olika ölsorters beska bestämmas. Beskan skulle bestämmas analytiskt genom två metoder, en HPCL och en spektrofotometrisk. Det skulle även avgöras vilken av metoderna som lämpade sig bäst för detta.
Linda, Ekeman
core +1 more source