Molecular modeling and phenoloxidase inhibitory activity of arbutin and arbutin undecylenic acid ester [PDF]
Biochemical and Biophysical Research Communications, 2021 Excessive melanin formation has been linked to various skin disorders such as hyperpigmentation and skin cancer. Tyrosinase is the most prominent target for inhibitors of melanin production. In this study, we investigated whether arbutin and its prodrug, arbutin undecylenic acid ester, might inhibit phenoloxidase (PO), a tyrosinase-like enzyme ...
Aki Hori, Ayu Masyita, Emil Salim
exaly +3 more sources
Chemical and Biocatalytic Routes to Arbutin † [PDF]
Molecules, 2019 Arbutin (also called β-arbutin) is a natural product occurring in the leaves of a variety of different plants, the bearberries of the Ericaceae and Saxifragaceae families being prominent examples.
Hangyu Zhou +3 more
doaj +4 more sources
Chemical and Pharmaceutical Bulletin, 2003 The effects of 4-hydroxyphenyl alpha-glucopyranoside (alpha-arbutin) and 4-hydroxyphenyl beta-glucopyranoside (arbutin) on the activity of tyrosinase from human malignant melanoma cells were examined. The inhibitory effect of alpha-arbutin on human tyrosinase was stronger than that of arbutin.
Takashi Kuriki +2 more
exaly +6 more sources
Arbutin attenuates nephrotoxicity induced by gentamicin [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: In this study, the impact of arbutin was examined in a gentamicin (GM)-induced nephrotoxicity model. Materials and Methods: Forty adult male Wistar rats were randomly assigned to five groups including control group; GM group, and three groups ...
Elnaz Emadi +5 more
doaj +3 more sources
Combination of enzyme engineering and quorum sensing system for efficient de novo biosynthesis of β-arbutin in Escherichia coli [PDF]
Synthetic and Systems Biotechnologyβ-Arbutin is a plant-derived glycoside with various biological activities, which has been applied in pharmaceuticals and whitening cosmetics. Uneven carbon flux distribution and the low catalytic efficiency of arbutin synthase limit the biosynthesis of β-
Zhuoyuan Liu +6 more
doaj +2 more sources
Antimicrobial action of α-arbutin, β-arbutin and hydroquinone: truth and fiction
Annals of Mechnikov's InstituteIntroduction. The leaves of lingonberry and bearberry are used in medicine for the treatment and prevention of urological infectious diseases due to the presence of diuretic and uroseptic action.
Oleksandr Maslov +6 more
doaj +3 more sources
Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent
Molecules, 2022 Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents.
Lutfun Nahar +2 more
exaly +3 more sources
Cucumber‐Derived Exosome‐Like Vesicles With Melanin‐Inhibitory Activity and an Acceptable in Vitro Safety Profile [PDF]
J Cosmet DermatolABSTRACT Background Skin hyperpigmentation disorders affect millions worldwide, driving demand for depigmentation products. However, many conventional skin‐lightening products contain dangerous ingredients, including mercury and unregulated hydroquinone.
Hsu C +6 more
europepmc +2 more sources
The phytochemical arbutin exerts potent anti-Toxoplasma effects through activation of cell-autonomous defense mechanisms while attenuating inflammation. [PDF]
PLoS Neglected Tropical DiseasesBackgroundPlant-derived natural products have emerged as promising candidates for developing novel anti-toxoplasmosis drugs. This study aimed to elucidate the role and mechanism of the phytochemical arbutin in the control of T.
Zhuanzhuan Liu +9 more
doaj +2 more sources
The In Vitro Wound-Scratch Assay: Applications, Technical Advances, and Limitations in Wound Healing Research. [PDF]
Int Wound JABSTRACT The wound‐scratch assay is a widely used in vitro model for studying collective cell migration, a fundamental process contributing to wound closure and re‐epithelialisation. Owing to its simplicity, low cost, and adaptability, it has become a foundational tool for early‐stage wound‐healing research and therapeutic screening. The assay involves
Molefe PF +3 more
europepmc +2 more sources