Results 21 to 30 of about 4,532 (170)

Arbutin as a potential nephroprotective agent: Dose-related effects in renal ischemia-reperfusion injury [PDF]

Biomolecules & Biomedicine
Ischemia-reperfusion injury (IRI) presents a complex pathophysiology characterized by oxidative stress and inflammation. Arbutin, widely recognized for its use in skin whitening, also exhibits antioxidant, anti-inflammatory, and anticancer properties ...
Ferhat Sirinyildiz, Izel Kavak, Nesibe Kahraman Cetin, Adem Keskin   +3 more
doaj   +2 more sources

Molecular modeling and phenoloxidase inhibitory activity of arbutin and arbutin undecylenic acid ester [PDF]

Biochemical and Biophysical Research Communications, 2021
Excessive melanin formation has been linked to various skin disorders such as hyperpigmentation and skin cancer. Tyrosinase is the most prominent target for inhibitors of melanin production. In this study, we investigated whether arbutin and its prodrug, arbutin undecylenic acid ester, might inhibit phenoloxidase (PO), a tyrosinase-like enzyme ...
Ayu Masyita, Emil Salim, Rangga Meidianto Asri, Firzan Nainu, Aki Hori, Risfah Yulianty, Mochammad Hatta, Yusnita Rifai, Takayuki Kuraishi   +8 more
openaire   +2 more sources

The In Vitro Wound-Scratch Assay: Applications, Technical Advances, and Limitations in Wound Healing Research. [PDF]

Int Wound J
ABSTRACT The wound‐scratch assay is a widely used in vitro model for studying collective cell migration, a fundamental process contributing to wound closure and re‐epithelialisation. Owing to its simplicity, low cost, and adaptability, it has become a foundational tool for early‐stage wound‐healing research and therapeutic screening. The assay involves
Molefe PF, Ghasemishahrestani Z, Khumalo NP, Bayat A.   +3 more
europepmc   +2 more sources

The Role of Gut Microbiota and Their Derived Metabolites in Chemotherapy-Induced Nausea and Vomiting in Ovarian Cancer. [PDF]

Cancer Med
ABSTRACT Objective This study aimed to investigate the relationship between gut microbiota and chemotherapy‐induced nausea and vomiting (CINV) in patients with ovarian cancer undergoing platinum‐based chemotherapy (carboplatin or cisplatin combined with paclitaxel).
Zu S, Yu X, Song J, Xiao Y, Yi H, Li H.
europepmc   +2 more sources

Türkiye'de Yetişen Üç Ahlat Türünün Arbutin İçeriğinin Değerlendirilmesi

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2020
Armut (Pyrus spp.) Dünya çapında en önemli meyvelerden biridir. Pyrus cinsi, Rosaceae ailesinin Pomoideae alt ailesine aittir. Pyrus türlerinin farklı organları farklı oranlarda arbutin içerir.
Rukiye Kayhan, İbrahim Bulduk, Safiye Elif Korcan, Emrah Şelli, Mustafa Kargıoğlu   +4 more
doaj   +1 more source

Arbutin effectively ameliorates the symptoms of Parkinson’s disease: the role of adenosine receptors and cyclic adenosine monophosphate

Neural Regeneration Research, 2021
An antagonistic communication exists between adenosinergic and dopaminergic signaling in the basal ganglia, which suggests that the suppression of adenosine A2A receptors-cyclic adenosine monophosphate pathway may be able to restore the disrupted ...
Jie Zhao, Manish Kumar, Jeevan Sharma, Zhihai Yuan   +3 more
doaj   +1 more source

Cucumber‐Derived Exosome‐Like Vesicles With Melanin‐Inhibitory Activity and an Acceptable in Vitro Safety Profile [PDF]

J Cosmet Dermatol
ABSTRACT Background Skin hyperpigmentation disorders affect millions worldwide, driving demand for depigmentation products. However, many conventional skin‐lightening products contain dangerous ingredients, including mercury and unregulated hydroquinone.
Hsu C, Chen W, Chen H, Liao Y, Hsieh C, Liu D, Cheng Y.   +6 more
europepmc   +2 more sources

Dual effects of alpha-arbutin on monophenolase and diphenolase activities of mushroom tyrosinase. [PDF]

PLoS ONE, 2014
The effects of α-arbutin on the monophenolase and diphenolase activities of mushroom tyrosinase were investigated. The results showed that α-arbutin inhibited monophenolase activity but it activated diphenolase activity.
Liang Qin, Yang Wu, Youting Liu, Yiming Chen, Peng Zhang   +4 more
doaj   +1 more source

Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway

Frontiers in Pharmacology, 2021
Background and objective: Abnormal activation of Janus kinase 2 (JAK2) promotes the pathogenesis and progress of inflammatory bowel disease (IBD) by stimulating the cytokine traffic.
Liang Wang, Liang Wang, Yuntao Feng, Jianwen Wang, Tenglong Luo, Xinyue Wang, Mengze Wu, Runxia Wang, Dapeng Chen, Jiyan Li, Jingyu Wang   +10 more
doaj   +1 more source

Enhancement of Skin Permeation and Penetration of β-Arbutin Fabricated in Chitosan Nanoparticles as the Delivery System

Cosmetics, 2022
Background: There has been an increase in demand for cosmetic skin-whitening products with efficacy toward lightening skin tone. β-arbutin is an inhibitor of tyrosinase enzyme activity within the skin’s melanocytes, and so has shown considerable promise ...
Shariza Sahudin, Nursyafiqah Sahrum Ayumi, Norsavina Kaharudin   +2 more
doaj   +1 more source