Results 41 to 50 of about 23,630,409 (308)

Use of HPLC-UV method for the analysis of maple syrup urine disease in plasma sample first time in Saudi Arabia

Journal of Biochemical and Clinical Genetics, 2018
Background: Measurement of branched-chain amino acids (BCAAs) [valine (Val), alloisoleucine (allo-Ile), isoleucine (Ile), and leucine (Leu)] in plasma and dry blood spot samples is important for the diagnosis and monitoring of maple syrup urine disease ...
Abdul Rafiq Khan, Ali Al-Othaim, Ahmed Al-Fares, Najla Al Hussain   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Development and validation of a HPLC method for quantification of sennosides A and B in senna leaves-containing herbal formulations (Cassia angustifolia) in Iran and comparison with spectrophotometric method [PDF]

مجله دانشگاه علوم پزشکی گیلان
Background: The leaves of Cassia angustifolia Vahl. have been used for the treatment of constipation and bowel evacuation. The main pharmacologically active constituents are sennosides A (SA) and B (SB).
Mahin Tayefeh, Fatemeh Yousefbeyk, Seyed Kazem Sadjady, Nasibeh Azizi, Saeed Ghasemi   +4 more
doaj  

Pharmacognostic, phytochemical, and chemomicroscopic evaluation of Physalis angulata (L)

The Proceedings of the Nigerian Academy of Science
Background/Introduction: Since the start of civilization, human culture has used plants to treat illnesses. Many plant samples have been adulterated intentionally or unintentionally during processing or even misidentified during collection.
Zainab B. Arowolo, Mubarak O. Ameen, Edehia Owen-Obaseki(, Ibrahim B. Gegele, Aliyu Adamu, Ruel C. Samuel, Jemilat A. Ibrahim, Teghtegh F. Samoh   +7 more
doaj   +1 more source

Evaluation of the clinical and quantitative performance of a practical HPLC-UV platform for in-hospital routine therapeutic drug monitoring of multiple drugs

Journal of Pharmaceutical Health Care and Sciences, 2023
Background In-hospital therapeutic drug monitoring (TDM) requires a suitable quantification method for target drugs from the viewpoint of precision, throughput, and testing costs. We previously developed a practical HPLC-UV platform for quantification of
Go Morikawa, Kazuto Fukami, Yukiko Moriiwa, Katsuko Okazawa, Akio Yanagida   +4 more
doaj   +1 more source

Artichoke leaf extracts: Proteolytic activity, coagulant and HPLC analysis

Ciência e Agrotecnologia, 2021
The search for origin plant-based proteases increases gradually due to their diversity and stability over a wide range of pH and temperature. Artichoke (Cynara scolymus) flowers are a proteolytic vegetable source already studied, but their leaves are ...
Gabriela Muricy de Souza Silva, Jessyka Silva da Costa, Janaina Oliveira Freire, Leandro Soares Santos, Renata Cristina Ferreira Bonomo   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Adaptation of Carum carvi L. to high altitudes: investigating the effect of altitude on seed physiological dormancy [PDF]

Journal of Medicinal Plants
Background: The relationship between altitude and seed dormancy in high-mountain plants, particularly in Carum carvi L., reveals significant insights into how environmental conditions influence seed viability and germination.
Mohsen Zafaranieh, Seyed Fazel Mirahmadi, Majid Ghorbani Nohooji   +2 more
doaj  

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source