Results 41 to 50 of about 110,023 (239)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Genotype distribution and molecular characterization of HPV in the Peruvian amazon: insights into prevalence, lineage diversity, and viral integration

Scientific Reports
Cervical cancer remains a leading cause of cancer-related mortality among women in Peru, with the highest death rates reported in the Amazon region. Despite this burden, molecular data on human papillomavirus (HPV) in this area are limited.
Lesly Solis-Ponce, Milan Stosic, Greisi Curicó, Susan Espetia, Heidy Sanchez-Grandez, Sadaf Sakina Hassan, Jorge Basiletti, Kristiane Søreng, Maribel Acuña-Barrios, Lilian Huarca-Balbin, Mariela Yaya-Ríos, Giovanny Vilcarino-Zevallos, Renzo Lopez, Andrea Matos, Cesar Ramal-Asayag, George Obregon, Laila Sara Arroyo Mühr   +16 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Kissing: Hullo hpv

Current Oncology, 2011
There are at least 5 types of kisses, including ges-tural, cultural, osculum, basium, saviolum, and oro-genital.[...]
openaire   +2 more sources

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

HPV

DST, 2008
Há quase 30 anos foram publicados os primeiros trabalhos iden­ tificando as sequências gênicas de uma família de pequenos vírus de DNA, dentre os quais alguns já tinham sido classifica­ dos como carcinogênicos em animais1. O trabalho pioneiro do francês Gérard Orth, da polonesa Stefania Jablonska, do alemão Harald zur Hausen, dos americanos Peter ...
  +6 more sources

Beta HPV Type 15 Can Interfere With NF-κB Activity and Apoptosis in Human Keratinocytes

Frontiers in Cellular and Infection Microbiology, 2020
E7 protein from cutaneous as well as mucosal HPV types can alter NF-κB activity. Conflicting literature data show a HPV-induced up- or down-regulation of the NF-κB pathway in different cell lines. In a previous study we detected the expression of E7 gene
Francesca Paolini, Francesca Paolini, Marco Zaccarini, Arianna Francesconi, Luciano Mariani, Luca Muscardin, Pietro Donati, Aldo Venuti, Aldo Venuti   +8 more
doaj   +1 more source

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source

Edge Information‐Augmented Auxiliary Diagnosis Method for Cervical Cancer in Medical Decision‐Making Systems

Advanced Intelligent Systems, EarlyView.
To address the problems of insufficient utilization of multiscale features and inefficient feature sharing between tasks in the model, this study proposes an edge‐enhanced intelligent cervical cancer screening method that achieves feature reuse and improves efficiency by jointly optimizing nucleolus segmentation and lesion classification.
Li Wen, Xiaoqing Zhang, Tingyi Dai, Fangfang Gou, Jia Wu   +4 more
wiley   +1 more source

Unveiling masturbatory sexual behaviours in Nigeria: insights into the prevalence and factors associated with self- and mutual masturbation among the sexually active population

BMC Public Health
Background Masturbation is a common practice across various demographics worldwide. However, its prevalence among the general population in Nigeria remains unknown.
Yusuf Bello, Deborah Oke, Temitope Ilori, Sikiru Adekola Adebayo, Tope Olubodun, Isaac Adewole, Suzanna Francis, Deborah Watson-Jones, Imran O. Morhason-Bello   +8 more
doaj   +1 more source