Results 121 to 130 of about 9,143 (202)
Scrotal squamous cell carcinoma: Two HPV‐negative cases with probable UV‐ induced pathogenesis
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Daniel Craus +7 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 35, 24 June 2026.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Quantification of HPV16-sperm interaction.
, 2013 Freshly ejaculated sperm cells were washed and incubated with Alexa488 labeled HPV16 capsids or the control protein Alexa488 MBP. Sperm-washing and the virus-sperm binding reactions were carried out as indicated at pH 8.6 or pH 7.4 (for buffer ...
Christopher B. Buck (121726) +2 more
core +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang +7 more
wiley +1 more source
Classical DDX activation occurs in response to nucleic acids. We found DDX6 activation in response to infection with HPV16 and with HPV16 L1 capsid infection, demonstrating DDX activation in response to a structural or morphologic aspect of the virion.
openaire +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Objective To investigate factors contributing to discrepancies between colposcopic‐directed biopsy (CDB) and conization in patients with cytology‐positive cervical lesions to reduce missed diagnoses of cervical cancer and unnecessary conizations.
Xiaojuan Zheng +5 more
wiley +1 more source
DDX17 was activated following infection with HPV16 but not in response to infection with HPV16L1 capsid, indicating viral nucleic acid was the trigger for DDX activation.
openaire +2 more sources
HPV16 variant distribution by diagnostic category.
, 2014 CIN3+: case group, comprising the samples from CIN 3 or worse (cervical cancer in situ or invasive);E: HPV16 European variant; NE: HPV16 non-European variant.
Robert D. Burk (35757) +6 more
core +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Persistent infection with high‐risk human papillomavirus (HR‐HPV) is defined as the principal cause of cervical cancer. Given the important role of cervicovaginal microbiota in HPV acquisition and disease progression, this study aims to evaluate the clinical efficacy of the probiotic Enterococcus faecium (E.
Jun Yang +6 more
wiley +1 more source
Examples of intragenic HPV16 DNA integration sites.
, 2013 (A) Tumor T182e has one HPV16 integration site 0182_DJ1, which is transcriptionally active (TA-group 1). The integrated HPV16 DNA is located in the intron (i) between exons (e) 5 and 6 of the cellular gene LIPC (transcript 003, Ensembl ID ...
Elisabeth Schwarz (83829) +6 more
core +1 more source