Results 1 to 10 of about 2,503,880 (309)
Pathogens, 2021 Epigallocatechin-3-gallate (EGCG), the primary bioactive polyphenol in green tea, has been shown to inhibit the growth of human papilloma virus (HPV)-transformed keratinocytes.
Jason K. W. Yap +3 more
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Research Progress of Proteolysis Targeting Chimeria in NSCLC Therapy
Chinese Journal of Lung Cancer, 2022 Proteolysis targeting chimeria (PROTAC) degrades target proteins by utilizing the ubiquitin-proteasome pathway, subverting the concept of traditional small molecule inhibitors.
Lin JIANG +4 more
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A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation. [PDF]
PLoS Pathogens, 2013 Adenoviral replication depends on viral as well as cellular proteins. However, little is known about cellular proteins promoting adenoviral replication.
Wilhelm Ching +8 more
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EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis
Frontiers in Cellular and Infection Microbiology, 2022 Viral oncogenes may drive cellular metabolic reprogramming to modulate the normal epithelia cell malignant transformation. Understanding the viral oncogene–mediated signaling transduction dysregulation that involves in metabolic reprogramming may provide
Tingting Yang +5 more
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PLoS Pathogens, 2021 Intracellular pathogens have evolved to utilize normal cellular processes to complete their replicative cycles. Pathogens that interface with proliferative cell signaling pathways risk infections that can lead to cancers, but the factors that influence ...
Adrian J Luna +14 more
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Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins
Biomolecules, 2020 Direct interaction between intrinsically disordered proteins (IDPs) is often difficult to characterize hampering the elucidation of their binding mechanism.
Maria Grazia Murrali +2 more
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Frontiers in Oncology, 2021 Although serum tumor markers (STMs), clinicopathological characteristics and the status of KRAS and MMR play an important role in optimizing the treatment and prognosis of colorectal cancer, their interrelationships remain largely unknown.
Ning Zhao +7 more
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Tumor Heterogeneity at Protein Level as an Independent Prognostic Factor in Endometrial Cancer
Translational Oncology, 2014 Intratumor heterogeneity implies heterogeneous protein function, facilitating tumor adaptation which results in therapeutic failure. We hypothesized that tumor heterogeneity at protein level may influence the course of the disease.
Anna Supernat +6 more
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PML degradation: multiple ways to eliminate PML.
Frontiers in Oncology, 2013 The promyelocytic leukemia gene (PML) critically regulates several cellular functions that oppose tumorigenesis such as oncogene-induced senescence, apoptosis, the response to DNA damage and to viral infections.
Andrea eRabellino, Pier Paolo eScaglioni
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CD81-Receptor Associations — Impact for Hepatitis C Virus Entry and Antiviral Therapies
Viruses, 2014 Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners.
Laetitia Zona +6 more
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