Results 1 to 10 of about 313,417 (170)
Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins [PDF]
International Journal of Molecular Sciences, 2022 Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that only encodes a few proteins, and it is also responsible for 5% of all human cancers, including cervical, vaginal, vulvar, penile, anal, and oropharyngeal cancers.
Daria A. Haręża +2 more
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Pathogens, 2021 Epigallocatechin-3-gallate (EGCG), the primary bioactive polyphenol in green tea, has been shown to inhibit the growth of human papilloma virus (HPV)-transformed keratinocytes.
Jason K. W. Yap +3 more
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Research Progress of Proteolysis Targeting Chimeria in NSCLC Therapy
Chinese Journal of Lung Cancer, 2022 Proteolysis targeting chimeria (PROTAC) degrades target proteins by utilizing the ubiquitin-proteasome pathway, subverting the concept of traditional small molecule inhibitors.
Lin JIANG +4 more
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A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation. [PDF]
PLoS Pathogens, 2013 Adenoviral replication depends on viral as well as cellular proteins. However, little is known about cellular proteins promoting adenoviral replication.
Wilhelm Ching +8 more
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Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait? [PDF]
Pathogens, 2016 Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins ...
Claire D. James, Sally Roberts
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EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis
Frontiers in Cellular and Infection Microbiology, 2022 Viral oncogenes may drive cellular metabolic reprogramming to modulate the normal epithelia cell malignant transformation. Understanding the viral oncogene–mediated signaling transduction dysregulation that involves in metabolic reprogramming may provide
Tingting Yang +5 more
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Requirement for c-ras proteins during viral oncogene transformation [PDF]
Nature, 1986 Many retroviral oncogenes have been classified into one of several categories based on structure, enzymology and cellular localization. These genes originated from host cells and are probably derived from genes normally involved in the control of cell proliferation. The cellular counterparts of three oncogenes have been identified as a growth factor or
Smith, Mark R. +2 more
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PLoS Pathogens, 2021 Intracellular pathogens have evolved to utilize normal cellular processes to complete their replicative cycles. Pathogens that interface with proliferative cell signaling pathways risk infections that can lead to cancers, but the factors that influence ...
Adrian J Luna +14 more
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Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV [PDF]
International Journal of Molecular Sciences, 2018 Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathogens.
Tamarozzi, Elvira, Giuliatti, Silvana
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mBio, 2021 As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.
Ling Wang +10 more
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