Results 1 to 10 of about 60,065 (147)

HBZ and its roles in HTLV-1 oncogenesis

Frontiers in Microbiology, 2012
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ).
Tiejun Zhao
exaly   +3 more sources

Splicing-dependent restriction of the HBZ gene by Tax underlies biphasic HTLV-1 infection. [PDF]

PLoS Pathogens
HTLV-1 is an oncovirus that encodes a transactivator Tax and a regulatory gene HBZ. HTLV-1 early or infectious replication depends on Tax; during HTLV-1 late infection, HBZ plays a crucial role in driving the proliferation of infected cells and ...
Yi Liang, Chenyang Lyu, Shuwen Xu, Chenxin Tan, Qian Jiang, Benquan Liu, Sikai Yang, Weijia Huang, Ruoning Zhou, Xiaoyi Yuan, Xiaorui Zuo, Masao Matsuoka, Guangyong Ma   +12 more
doaj   +2 more sources

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5

Frontiers in Microbiology, 2018
Human T-cell leukemia virus type 1 (HTLV-1) encodes a protein derived from the antisense strand of the proviral genome designated HBZ (HTLV-1 basic leucine zipper factor). HBZ is the only viral gene consistently expressed in infected patients and adult T-
Jacob Al-Saleem, Patrick Green, Cory Howard   +2 more
exaly   +3 more sources

The Role of HBZ in HTLV-1-Induced Oncogenesis

Viruses, 2016
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and chronic inflammatory diseases. HTLV-1 bZIP factor (HBZ) is transcribed as an antisense transcript of the HTLV-1 provirus.
Tiejun Zhao
exaly   +3 more sources

HTLV-1 HBZ Protein Resides Exclusively in the Cytoplasm of Infected Cells in Asymptomatic Carriers and HAM/TSP Patients

Frontiers in Microbiology, 2019
Human T cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a subset of infected subjects.
Claudine Piqué, Greta Forlani, Roberto Accolla   +2 more
exaly   +3 more sources

HTLV-1 Tax and HBZ cooperatively promote leukemogenesis through miR-155-mediated PTEN suppression and PI3K-Akt activation [PDF]

Journal of Virology
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL), but the full scope of its oncogenic mechanisms remains elusive.
Xiaoru Xin, Yu Mao, Qianan Li, Xinyi Wang, Jinyong Fang, Tiejun Zhao   +5 more
doaj   +2 more sources

Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP

Frontiers in Microbiology, 2017
Human T cell lymphotropic virus type 1 (HTLV-1) infection can lead to development of adult T cell leukemia/lymphoma (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a subset of infected subjects.
Yoshimi Enose-Akahata, Steven Jacobson
exaly   +3 more sources

HTLV-1 Hbz protein, but not hbz mRNA secondary structure, is critical for viral persistence and disease development.

PLoS Pathogens, 2023
Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic cause of adult T-cell leukemia/lymphoma (ATL) and encodes a viral oncoprotein (Hbz) that is consistently expressed in asymptomatic carriers and ATL patients, suggesting its importance in the ...
Victoria Maksimova, Tasha Wilkie, Susan Smith, Cameron Phelps, Corrine Melvin, Lianbo Yu, Stefan Niewiesk, Patrick L Green, Amanda R Panfil   +8 more
doaj   +1 more source

The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing

Frontiers in Immunology, 2022
Adult T-cell leukemia/lymphoma (ATL) is a T-cell lymphoproliferative neoplasm caused by the human T-cell leukemia virus type 1 (HTLV-1). Two viral proteins, Tax-1 and HBZ play important roles in HTLV-1 infectivity and in HTLV-1-associated pathologies by ...
Mariam Shallak, Tiziana Alberio, Mauro Fasano, Maria Monti, Maria Monti, Ilaria Iacobucci, Ilaria Iacobucci, Julien Ladet, Franck Mortreux, Roberto S. Accolla, Greta Forlani   +10 more
doaj   +1 more source

TAX and HBZ: hFc Ɣ 1 proteins as targets for passive immunotherapy [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Human T leukemia virus type one (HTLV-1) causes two life-threatening diseases in around five percent of infected subjects, a T cell malignancy and a neurodegenerative disease.
Mohammad Akbarin, Houshang Rafatpanah, Saman Soleimanpour, Abbas Amini, Amirali Arian, Arman Mosavat, Seyed Abdolrahim Rezaee   +6 more
doaj   +1 more source