Results 31 to 40 of about 2,503,880 (309)
Characterization of the Phosphoproteome in SLE Patients. [PDF]
PLoS ONE, 2012 Protein phosphorylation is a complex regulatory event that is involved in the signaling networks that affect virtually every cellular process. The protein phosphorylation may be a novel source for discovering biomarkers and drug targets.
Xinzhou Zhang +3 more
doaj +1 more source
Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas [PDF]
Proceedings of the National Academy of Sciences, 1999 Medulloblastoma represents greater than 25% of childhood intracranial neoplasms and is considered a highly malignant tumor. This tumor, which arises predominantly in the cerebellar vermis, preferentially affects children between the ages of 5 and 15. Although the etiology of medulloblastomas in humans remains unknown, results from several experiments ...
Krynska B. +7 more
openaire +3 more sources
mBio, 2020 Extracellular vesicles (EVs) are important mediators of cell-to-cell communication that are involved in both normal processes and pathological conditions.
Dingani Nkosi +6 more
doaj +1 more source
Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. [PDF]
, 2011 The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression.
Baiker Armin +28 more
core +2 more sources
Long Non-coding RNA DANCR as an Emerging Therapeutic Target in Human Cancers
Frontiers in Oncology, 2019 Long noncoding RNAs (lncRNAs) are emerging as important regulators of numerous biological processes, especially in cancer development. Aberrantly expressed and specifically located in tumor cells, they exert distinct functions in different cancers via ...
Shi-Jia Jin +5 more
doaj +1 more source
Transactivation by the E2 Protein of Oncogenic Human Papillomavirus Type 31 Is Not Essential for Early and Late Viral Functions [PDF]
Journal of Virology, 1998 ABSTRACT The activation of transcription and of DNA replication are, in some cases, mediated by the same proteins. A prime example is the E2 protein of human papillomaviruses (HPVs), which binds ACCN 6 GGT sequences and activates heterologous promoters from multimerized binding sites.
F, Stubenrauch +2 more
openaire +2 more sources
The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus [PDF]
, 2010 Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein.
Peeters, B.P.H. +7 more
core +1 more source
mBio, 2020 Kaposi’s sarcoma-associated herpesvirus (KSHV) causes primary effusion lymphoma (PEL). The cellular transcription factor (TF) interferon (IFN) regulatory factor 4 (IRF4) is an essential oncogene in PEL, but its specific role in PEL and how KSHV ...
Mark Manzano +6 more
doaj +1 more source
Natural Product Communications, 2022 Despite accumulating evidence for the value of herbal drugs for cancer treatment, the mechanisms underlying their effects have not been fully elucidated in a systematic manner.
Ho-Sung Lee +7 more
doaj +1 more source
The Oncogenic Effects, Pathways, and Target Molecules of JC Polyoma Virus T Antigen in Cancer Cells
Frontiers in Oncology, 2022 JC polyoma virus (JCPyV) is a ubiquitous polyoma virus that infects the individual to cause progressive multifocal leukoencephalopathy and malignancies.
Hua-Chuan Zheng +4 more
doaj +1 more source