Results 11 to 20 of about 313,516 (269)
Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins
Biomolecules, 2020 Direct interaction between intrinsically disordered proteins (IDPs) is often difficult to characterize hampering the elucidation of their binding mechanism.
Maria Grazia Murrali +2 more
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Frontiers in Oncology, 2021 Although serum tumor markers (STMs), clinicopathological characteristics and the status of KRAS and MMR play an important role in optimizing the treatment and prognosis of colorectal cancer, their interrelationships remain largely unknown.
Ning Zhao +7 more
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Tumor Heterogeneity at Protein Level as an Independent Prognostic Factor in Endometrial Cancer
Translational Oncology, 2014 Intratumor heterogeneity implies heterogeneous protein function, facilitating tumor adaptation which results in therapeutic failure. We hypothesized that tumor heterogeneity at protein level may influence the course of the disease.
Anna Supernat +6 more
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PML degradation: multiple ways to eliminate PML.
Frontiers in Oncology, 2013 The promyelocytic leukemia gene (PML) critically regulates several cellular functions that oppose tumorigenesis such as oncogene-induced senescence, apoptosis, the response to DNA damage and to viral infections.
Andrea eRabellino, Pier Paolo eScaglioni
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Oncogenic Viral Protein Interactions with p53 Family Proteins
Klinicka Onkologie, 2019 Cellular transformation induced by oncogenic viruses is a complex process including viral molecules, host cells and environmental factors. Viruses alone are unable to reproduce and thus they need a host to use their signalling, proteosynthetic and metabolic pathways. One target host molecule is the p53 tumour suppressor.
V, Brychtová, V, Hrabal, B, Vojtěšek
openaire +2 more sources
CD81-Receptor Associations — Impact for Hepatitis C Virus Entry and Antiviral Therapies
Viruses, 2014 Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners.
Laetitia Zona +6 more
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Persistent human papillomavirus infection in the etiology of cervical carcinoma: The role of immunological, genetic, viral and cellular factors [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2014 The aim of this paper was to present the role of human papillomavirus (HPV) in cervical carcinogenesis from several aspects. By explaining the HPV virus lifecycle and structure, its effect on cervical cell cycle and subversion of immune response
Živadinović Radomir +4 more
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TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1 [PDF]
The EMBO Journal, 2001 The oncogenic latent membrane protein 1 (LMP1) of the Epstein-Barr virus recruits tumor necrosis factor-receptor (TNFR)-associated factors (TRAFs), the TNFR-associated death domain protein (TRADD) and JAK3 to induce intracellular signaling pathways.
U, Schultheiss +6 more
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Interaction of viral oncogenic proteins with the Wnt signaling pathway.
Iranian journal of basic medical sciences, 2018 It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses ...
Khanizadeh, Sayyad +4 more
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Cancer Cell International, 2020 The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the function of these two proteins.
Gao-Qi Wu, Yan-Ming Xu, Andy T. Y. Lau
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