Results 11 to 20 of about 2,503,880 (309)
Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins [PDF]
International Journal of Molecular Sciences, 2022 Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that only encodes a few proteins, and it is also responsible for 5% of all human cancers, including cervical, vaginal, vulvar, penile, anal, and oropharyngeal cancers.
Daria A. Haręża +2 more
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Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait? [PDF]
Pathogens, 2016 Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins ...
Claire D. James, Sally Roberts
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Requirement for c-ras proteins during viral oncogene transformation [PDF]
Nature, 1986 Many retroviral oncogenes have been classified into one of several categories based on structure, enzymology and cellular localization. These genes originated from host cells and are probably derived from genes normally involved in the control of cell proliferation. The cellular counterparts of three oncogenes have been identified as a growth factor or
Smith, Mark R. +2 more
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Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV [PDF]
International Journal of Molecular Sciences, 2018 Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathogens.
Tamarozzi, Elvira, Giuliatti, Silvana
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mBio, 2021 As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.
Ling Wang +10 more
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Adenovirus and its interaction with host cell proteins [PDF]
, 2007 The E1B55k gene in adenovirus type 5 was studied by generating recombinant viruses in which the E1B55k gene was N-terminally tagged with either a cyan fluorescent protein (CFP) tag or a tandem affinity purification (TAP) tag.
Carr, Sharon
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Dominant-Negative Proteins in Herpesviruses - From Assigning Gene Function to Intracellular Immunization [PDF]
, 2009 Investigating and assigning gene functions of herpesviruses is a process, which profits from consistent technical innovation. Cloning of bacterial artificial chromosomes encoding herpesvirus genomes permits nearly unlimited possibilities in the ...
Christian A. Mohr +9 more
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Oncogenic Viral Protein Interactions with p53 Family Proteins
Klinicka Onkologie, 2019 Cellular transformation induced by oncogenic viruses is a complex process including viral molecules, host cells and environmental factors. Viruses alone are unable to reproduce and thus they need a host to use their signalling, proteosynthetic and metabolic pathways. One target host molecule is the p53 tumour suppressor.
V, Brychtová, V, Hrabal, B, Vojtěšek
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TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1 [PDF]
The EMBO Journal, 2001 The oncogenic latent membrane protein 1 (LMP1) of the Epstein-Barr virus recruits tumor necrosis factor-receptor (TNFR)-associated factors (TRAFs), the TNFR-associated death domain protein (TRADD) and JAK3 to induce intracellular signaling pathways.
U, Schultheiss +6 more
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Persistent human papillomavirus infection in the etiology of cervical carcinoma: The role of immunological, genetic, viral and cellular factors [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2014 The aim of this paper was to present the role of human papillomavirus (HPV) in cervical carcinogenesis from several aspects. By explaining the HPV virus lifecycle and structure, its effect on cervical cell cycle and subversion of immune response
Živadinović Radomir +4 more
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