Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins [PDF]
International Journal of Molecular Sciences, 2022 Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that only encodes a few proteins, and it is also responsible for 5% of all human cancers, including cervical, vaginal, vulvar, penile, anal, and oropharyngeal cancers.
Daria A. Haręża +2 more
openaire +2 more sources
Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait? [PDF]
Pathogens, 2016 Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins ...
Claire D. James, Sally Roberts
openaire +3 more sources
Requirement for c-ras proteins during viral oncogene transformation [PDF]
Nature, 1986 Many retroviral oncogenes have been classified into one of several categories based on structure, enzymology and cellular localization. These genes originated from host cells and are probably derived from genes normally involved in the control of cell proliferation. The cellular counterparts of three oncogenes have been identified as a growth factor or
Smith, Mark R. +2 more
openaire +2 more sources
Adenovirus-Mediated Sensitization to the Cytotoxic Drugs Docetaxel and Mitoxantrone Is Dependent on Regulatory Domains in the E1ACR1 Gene-Region [PDF]
, 2012 Oncolytic adenoviruses have shown promising efficacy in clinical trials targeting prostate cancers that frequently develop resistance to all current therapies.
Daniel Öberg +7 more
core +8 more sources
Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV [PDF]
International Journal of Molecular Sciences, 2018 Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathogens.
Elvira Tamarozzi, Silvana Giuliatti
openaire +2 more sources
mBio, 2021 As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.
Ling Wang +10 more
openaire +4 more sources
Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications [PDF]
, 2018 The Epstein-Barr virus (EBV) is a ubiquitous human \u3b3-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies.
Celeghin, Andrea +4 more
core +1 more source
Oncogenic Viral Protein Interactions with p53 Family Proteins
Klinicka Onkologie, 2019 Cellular transformation induced by oncogenic viruses is a complex process including viral molecules, host cells and environmental factors. Viruses alone are unable to reproduce and thus they need a host to use their signalling, proteosynthetic and metabolic pathways. One target host molecule is the p53 tumour suppressor.
V, Brychtová, V, Hrabal, B, Vojtěšek
openaire +2 more sources
TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1 [PDF]
The EMBO Journal, 2001 The oncogenic latent membrane protein 1 (LMP1) of the Epstein-Barr virus recruits tumor necrosis factor-receptor (TNFR)-associated factors (TRAFs), the TNFR-associated death domain protein (TRADD) and JAK3 to induce intracellular signaling pathways.
U, Schultheiss +6 more
openaire +2 more sources
Protein transduction: A novel tool for tissue regeneration [PDF]
, 2002 Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Derer W. +4 more
core +1 more source