Haematologica, 2013 Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the Mixed Lineage Leukemia (MLL) gene.
Emma M.C. Driessen +7 more
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Liver Cell Transformation in Chronic HBV Infection
Viruses, 2009 Epidemiological studies have provided overwhelming evidence for a causal role of chronic HBV infection in the development of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying virally-induced tumorigenesis remain largely debated.
Marie Annick Buendia +3 more
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Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells [PDF]
Aging, 2009 Senescence is blocked in human cervical keratinocytes infected with high risk human papillomavirus (e.g. HPV type16). Viral oncoproteins HPV E6 and HPV E7 access the cell cycle via cellular p53 and retinoblastoma proteins respectively. Previously we have shown that HPV E7, not HPV E6, is also responsible for cervical cancer cell survival (SiHa cells ...
Allison, Simon J. +2 more
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Characterization of the Phosphoproteome in SLE Patients. [PDF]
PLoS ONE, 2012 Protein phosphorylation is a complex regulatory event that is involved in the signaling networks that affect virtually every cellular process. The protein phosphorylation may be a novel source for discovering biomarkers and drug targets.
Xinzhou Zhang +3 more
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Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas [PDF]
Proceedings of the National Academy of Sciences, 1999 Medulloblastoma represents greater than 25% of childhood intracranial neoplasms and is considered a highly malignant tumor. This tumor, which arises predominantly in the cerebellar vermis, preferentially affects children between the ages of 5 and 15. Although the etiology of medulloblastomas in humans remains unknown, results from several experiments ...
Krynska B. +7 more
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mBio, 2020 Extracellular vesicles (EVs) are important mediators of cell-to-cell communication that are involved in both normal processes and pathological conditions.
Dingani Nkosi +6 more
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The Oncogenic Effects, Pathways, and Target Molecules of JC Polyoma Virus T Antigen in Cancer Cells
Frontiers in Oncology, 2022 JC polyoma virus (JCPyV) is a ubiquitous polyoma virus that infects the individual to cause progressive multifocal leukoencephalopathy and malignancies.
Hua-Chuan Zheng +4 more
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Association of Clinicopathological Profile and Immunohistochemical Expression of KRAS and BRAF in Colorectal Carcinoma: A Cross-sectional Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Colorectal Carcinoma (CRC) is a multi-step process that occurs due to the accumulation of several genetic alterations. The most important alterations are related to the rat sarcoma viral oncogene homolog (RAS) and Rapidly Accelerated ...
Mandira Mitra +3 more
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Transactivation by the E2 Protein of Oncogenic Human Papillomavirus Type 31 Is Not Essential for Early and Late Viral Functions [PDF]
Journal of Virology, 1998 ABSTRACT The activation of transcription and of DNA replication are, in some cases, mediated by the same proteins. A prime example is the E2 protein of human papillomaviruses (HPVs), which binds ACCN 6 GGT sequences and activates heterologous promoters from multimerized binding sites.
F, Stubenrauch +2 more
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Long Non-coding RNA DANCR as an Emerging Therapeutic Target in Human Cancers
Frontiers in Oncology, 2019 Long noncoding RNAs (lncRNAs) are emerging as important regulators of numerous biological processes, especially in cancer development. Aberrantly expressed and specifically located in tumor cells, they exert distinct functions in different cancers via ...
Shi-Jia Jin +5 more
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