Results 21 to 30 of about 2,503,880 (309)

Interaction of viral oncogenic proteins with the Wnt signaling pathway.

Iranian journal of basic medical sciences, 2018
It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses ...
Khanizadeh, Sayyad, Hasanvand, Banafshe, Esmaeil Lashgarian, Hamed, Almasian, Mohammad, Goudarzi, Gholamreza   +4 more
openaire   +3 more sources

KRAS (Kirsten rat sarcoma viral oncogene homolog) [PDF]

, 1999
Review on KRAS (Kirsten rat sarcoma viral oncogene homolog), with data on DNA, on the protein encoded, and where the gene is ...
Lion, T, T Lion, Watzinger, F, F Watzinger   +3 more
core   +1 more source

HRAS (Harvey rat sarcoma viral oncogene homolog) [PDF]

, 1999
Review on HRAS (Harvey rat sarcoma viral oncogene homolog), with data on DNA, on the protein encoded, and where the gene is ...
Lion, T, T Lion, Watzinger, F, F Watzinger   +3 more
core   +1 more source

Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants

Haematologica, 2013
Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the Mixed Lineage Leukemia (MLL) gene.
Emma M.C. Driessen, Eddy H.J. van Roon, Jill A.P. Spijkers-Hagelstein, Pauline Schneider, Paola de Lorenzo, Maria Grazia Valsecchi, Rob Pieters, Ronald W. Stam   +7 more
doaj   +1 more source

Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease

Cancer Cell International, 2020
The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the function of these two proteins.
Gao-Qi Wu, Yan-Ming Xu, Andy T. Y. Lau
doaj   +1 more source

N-RAS (neuroblastoma RAS viral oncogene homolog) [PDF]

, 1999
Review on N-RAS (neuroblastoma RAS viral oncogene homolog), with data on DNA, on the protein encoded, and where the gene is ...
Lion, T, Watzinger, F
core   +1 more source

Viral interferon antagonists and antiviral drugs [PDF]

, 2009
For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs.
Nobre, Rita
core   +2 more sources

Liver Cell Transformation in Chronic HBV Infection

Viruses, 2009
Epidemiological studies have provided overwhelming evidence for a causal role of chronic HBV infection in the development of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying virally-induced tumorigenesis remain largely debated.
Marie Annick Buendia, Delphine Cougot, Shirine Benhenda, Christine Neuveut   +3 more
doaj   +1 more source

Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells [PDF]

Aging, 2009
Senescence is blocked in human cervical keratinocytes infected with high risk human papillomavirus (e.g. HPV type16). Viral oncoproteins HPV E6 and HPV E7 access the cell cycle via cellular p53 and retinoblastoma proteins respectively. Previously we have shown that HPV E7, not HPV E6, is also responsible for cervical cancer cell survival (SiHa cells ...
Allison, Simon J., Jiang, Ming, Milner, Jo   +2 more
openaire   +2 more sources

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Wiertz, E.J.H.J., Thomas C Mettenleiter, Jacques J Neefjes, Wang, Ying, Koch, J., Mirjam H M Heemskerk, Loch Sandra, Marieke C Verweij, Daus, Franz, Nikolaus Osterrieder, Neefjes, J.J., Tampe, R., Chowdhury, Shafiqul I., Osterrieder, Nikolaus, Loch, S., Edwin Quinten, Rijsewijk, Frans A. M., Quinten, E., Neefjes, Jacques J., Ressing, Maaike E., Lipinska, A.D., Krystyna Bieńkowska-Szewczyk, Verweij Marieke C., Koch Joachim, Danijela Koppers-Lalic, Neefjes Jacques J., Wiertz, Emmanuel J. H. J., Koppers-Lalic, Danijela, Mettenleiter, T.C., Lipińska Andrea D., Rezende Marisa Marcondes, Ressing Maaike E., Emmanuel J H J Wiertz, Lipinska, Andrea D., Tampé Robert, Verweij, M.C., Ressing, M.E., Ying Wang, Wang, Y., Koch, Joachim, Heemskerk, Mirjam H. M., Sandra Loch, Marisa Marcondes Rezende, Tampé, Robert, Daus, F.J., Reits, E.A., Wiertz Emmanuel J. H. J., Shafiqul I Chowdhury, Loch, Sandra, Koppers-Lalic Danijela, Osterrieder, N., Quinten, Edwin, Rezende, M.M., Robert Tampé, Verweij, Marieke C., Joachim Koch, Franz Daus, Mettenleiter Thomas C., Bienkowska-Szewczyk, K., Rijsewijk, F.A.M., Eric A Reits, Heemskerk Mirjam H. M., Mettenleiter, Thomas C., Maaike E Ressing, Reits Eric A., Marcondes Rezende, Marisa, Chowdhury, S.I., Osterrieder Nikolaus, Daus Franz, Quinten Edwin, Koppers-Lalic, D., Reits, Eric A., Bienkowska-Szewczyk, Krystyna, Andrea D Lipińska, Frans A M Rijsewijk, Bieńkowska-Szewczyk Krystyna, Wang Ying, Rijsewijk Frans A. M., Heemskerk, M.H.M., Chowdhury Shafiqul I., Daus, F.   +80 more
core   +2 more sources