Results 41 to 50 of about 510 (124)
Glucosylceramide biosynthesis pathway is essential for HRTV infection.
, 2023 A. Diagram of glycosphingolipid biosynthesis pathway. Genes highlighted in red were identified from CRISPR/Cas9 screen. B-C. Effect of NB-DNJ or UGT8-IN on HRTV replication. 293T cells were pre-treated with NB-DNJ or UGT8-IN for 24 hours before infection
Kyle Jung (14797229) +10 more
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Replication-competent HRTV or DBV pseudotyped viruses require GlcCer for efficient entry.
, 2023 A. Diagram of replication-competent rVSV-DBV genome. B. Replication-competent rVSV-HRTV entry in SPTLC2-, UGCG- or UGT8-deficiency cells. Control and KO 293T cells were infected with replication-competent rVSV-HRTV for 16 hours, followed by flow ...
Kyle Jung (14797229) +10 more
core +1 more source
HRTV glycoproteins are responsible for GlcCer-mediated membrane fusion.
, 2023 A. Effect of SPTLC2-, UGCG- or UGT8-deficiency on rVSV-HRTV, rVSV-DBV, and rVSV-G entry. Control and KO 293T cells were infected with the indicated virus for 24 hours, followed by luciferase assay.
Kyle Jung (14797229) +10 more
core +1 more source
HRTV requires GlcCer for efficient infection in HeLa cell.
, 2023 A. Knockout efficiency of SPTLC2-, UGCG- or UGT8 gene in HeLa cell lines was measured by qPCR. Data shown are means ± SEM from representative experiments (n = 3 technical replicates). P values were determined by multiple unpaired t-tests.
Kyle Jung (14797229) +10 more
core +1 more source
Heartland Virus Neutralizing Antibodies in Vertebrate Wildlife, United States, 2009–2014
Emerging Infectious Diseases, 2015 Since its discovery in 2009, the tickborne Heartland virus (HRTV) has caused human illness in Missouri, Oklahoma, and Tennessee USA. To better assess the geographic distribution of HRTV, we used wildlife serology as an indicator.
Kasen K. Riemersma, Nicholas Komar
doaj +1 more source
Role of glycosphingolipid biosynthesis pathway in HRTV and DBV entry.
, 2023 Sphingolipid de novo synthesis pathway is initiated in the ER, where palmitoyl-CoA and serine are catalyzed into ceramide by enzymes, including SPT and CerS.
Kyle Jung (14797229) +10 more
core +1 more source
The genome sequence of Lone Star virus, a highly divergent bunyavirus found in the Amblyomma americanum tick. [PDF]
PLoS ONE, 2013 Viruses in the family Bunyaviridae infect a wide range of plant, insect, and animal hosts. Tick-borne bunyaviruses in the Phlebovirus genus, including Severe Fever with Thrombocytopenia Syndrome virus (SFTSV) in China, Heartland virus (HRTV) in the ...
Andrea Swei +7 more
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Heartland Virus Transmission, Suffolk County, New York, USA
Emerging Infectious Diseases, 2021 During 2018, Heartland virus RNA was detected in an Amblyomma americanum tick removed from a resident of Suffolk County, New York, USA. The person showed seroconversion.
Alan P. Dupuis +14 more
doaj +1 more source
Pathogens, 2022 As demonstrated by the 2015 Zika virus outbreak in the Americas, emerging and re-emerging arboviruses are public health threats that warrant research investment for the development of effective prophylactics and therapeutics.
Yuxiang Wang +3 more
doaj +1 more source
Frontiers in Microbiology, 2021 Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the tick-borne SFTS bunyavirus (SFTSV) resulting in a high fatality rate up to 30%.
Fuli Ren +20 more
doaj +1 more source