Results 21 to 30 of about 510 (124)
Differential Antagonism of Human Innate Immune Responses by Tick-Borne
mSphere, 2017 In recent years, several newly discovered tick-borne viruses causing a wide spectrum of diseases in humans have been ascribed to the Phlebovirus genus of the Bunyaviridae family.
Veronica V. Rezelj +5 more
doaj +2 more sources
Current insights into human pathogenic phenuiviruses and the host immune system [PDF]
VirulencePhenuiviruses are a class of segmented negative-sense single-stranded RNA viruses, typically consisting of three RNA segments that encode four distinct proteins. The emergence of pathogenic phenuivirus strains, such as Rift Valley fever phlebovirus (RVFV)
Chuan-Min Zhou +3 more
doaj +2 more sources
Comparative Analysis of Bisexual and Parthenogenetic Populations in Haemaphysalis Longicornis [PDF]
MicroorganismsHaemaphysalis longicornis, a three-host tick with a wide host range, is widely distributed in different countries and regions. It stands out among ticks due to its unique feature of having both parthenogenetic and bisexual populations.
Chaoyue Zhao +5 more
doaj +2 more sources
Focal persistence and phylodynamics of Heartland virus in Georgia [PDF]
Virus EvolutionGonzalo Vazquez-Prokopec +2 more
exaly +2 more sources
Isolation of Heartland Virus from Lone Star Ticks, Georgia, USA, 2019
Emerging Infectious Diseases, 2022 Report of a human death and exposure of white-tailed deer to Heartland virus (HRTV) in Georgia, USA, prompted the sampling of questing ticks during 2018–2019 in 26 sites near where seropositive deer were captured and the residence of the human case ...
Yamila Romer +8 more
doaj +1 more source
Humoral immunity to phlebovirus infection
Annals of the New York Academy of Sciences, Volume 1530, Issue 1, Page 23-31, December 2023., 2023 Phleboviruses are global zoonotic pathogens that can cause severe disease when transmitted to humans. Here we discuss how studying antibody responses during natural infection and the identification of neutralizing epitopes on the mature polyproteins Gn and Gc are informing the development of phlebovirus vaccines.
Katie J. Doores
wiley +1 more source
ISG20: an enigmatic antiviral RNase targeting multiple viruses
FEBS Open Bio, Volume 12, Issue 6, Page 1096-1111, June 2022., 2022 ISG20 is a broad antiviral inhibitor and a potent RNase in vitro. However, a precise understanding of its mechanism of action is lacking. In this review, we discuss the latest developments on this fascinating innate defense factor. Interferon‐stimulated gene 20 kDa protein (ISG20) is a relatively understudied antiviral protein capable of inhibiting a ...
Séverine Deymier +3 more
wiley +1 more source
Enzymatic Assays to Explore Viral mRNA Capping Machinery
ChemBioChem, Volume 22, Issue 23, Page 3236-3253, December 2, 2021., 2021 To escape recognition by the host innate immune system, viruses often incorporate 5′ caps into their mRNAs. The differences in mRNA capping make this process an interesting therapeutic target. Here, we review methods to explore the enzymes involved in cap biosynthesis. Such methods allow inhibitor selection, facilitating antiviral drug discovery, which
Renata Kasprzyk, Jacek Jemielity
wiley +1 more source
Journal of the World Aquaculture Society, Volume 52, Issue 6, Page 1221-1233, December 2021., 2021 Abstract Bottom center drain circular tanks in which water is injected tangentially to the tank wall are widely used in aquaculture. However, a torus‐shaped region about the center drain can develop into an irrotational zone that generates low velocities and poor mixing.
Myong‐Guk Sin +4 more
wiley +1 more source
Environmental Microbiology, Volume 23, Issue 7, Page 3477-3498, July 2021., 2021 Summary Microbial communities in hypersaline underground waters derive from ancient organisms trapped within the evaporitic salt crystals and are part of the poorly known subterranean biosphere. Here, we characterized the viral and prokaryotic assemblages present in the hypersaline springs that dissolve Triassic‐Keuper evaporite rocks and feed the ...
Mª Dolores Ramos‐Barbero +9 more
wiley +1 more source