Results 71 to 80 of about 48,111 (219)
ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
iNew Medicine, EarlyView.ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This study refines conventional lymphopenia grading by establishing optimized T‐cell cutoffs via flow cytometric lymphocyte subset profiling. Additionally, by evaluating individual subset performance (CD4+, CD8+, B, and NK cells), the framework integrates these counts to construct predictive models for infection‐associated inflammation.
Shicheng Li +5 more
wiley +1 more source
Takotsubo cardiomyopathy during armed conflict: A case series
ESC Heart Failure, Volume 12, Issue 2, Page 1494-1498, April 2025.
Sharon Bruoha +13 more
wiley +1 more source
Racial and ethnic differences in hospital‐based low‐value pediatric care
Journal of Hospital Medicine, EarlyView.Abstract Background Low‐value care (LVC), or care in which potential risk outweighs perceived benefits, continues to impact pediatric populations. While pediatric healthcare delivery is known to vary across racial and ethnic groups, little is known about the relationship between race and ethnicity and LVC.
Elisha McCoy +14 more
wiley +1 more source
Journal of Periodontology, EarlyView.Abstract Background This study investigated the cross‐sectional association between periodontal status and left ventricular (LV) geometry and function, an early and prognostically relevant marker of cardiovascular disease. Methods Data were drawn from two population‐based cohorts in the Study of Health in Pomerania (SHIP): SHIP‐START‐2 (N = 2333) and ...
Maja Trost +8 more
wiley +1 more source
Journal of Nutrition and Metabolism, 2012 Elevated serum high-sensitivity C-reactive protein (hs-CRP) and low serum 25-hydroxyvitamin D [25(OH)D] are associated with increased cardiovascular disease (CVD) risk.
Ambika P. Ashraf +6 more
doaj +1 more source
The ImproveCareNow Registry: Prediction of different remission rates in pediatric ulcerative colitis
JPGN Reports, EarlyView.Abstract Objectives Identifying predictors of clinical remission in pediatric ulcerative colitis (UC) will impact the therapeutic approach. We aimed to predict time to first (TFR), corticosteroid‐free (TCSFR, ≥3 months corticosteroid withdrawal), and sustained remission (TSR, ≥6 months).
Jonathan Van Hecke +7 more
wiley +1 more source
Journal of Surgical Oncology, EarlyView.ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis despite surgical resection, yet the prognostic literature remains fragmented across hundreds of single‐institution studies that vary in design, covariates, and analytical approaches.
Muhammad Maisam Ali +8 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT The impacts of cardiometabolic risk factors (CMRFs) and the biomarkers on disease severity in metabolic dysfunction‐associated steatotic liver disease (MASLD) remain elusive. Accordingly, a multicenter study by recruiting MASLD patients from a nationwide registry database was conducted with a total of 2882 MASLD patients (54.1% males, mean age
Jee‐Fu Huang +14 more
wiley +1 more source
Nutrition in Clinical Practice, EarlyView.Abstract Background Perianal involvement occurs in up to 50% of patients with Crohn's disease (CD). Despite combined management, 10%–20% require fecal diversion or proctectomy. Nutritional status may influence prognosis, but its role in fistulizing perianal disease is unclear.
Bruno Augusto Alves Martins +7 more
wiley +1 more source