Results 101 to 110 of about 73,273 (215)

Development of CAR NK Cell Lines Selectively Targeting Cancer Cells Expressing Membrane Hsp70. [PDF]

MedComm (2020)
Hachani K, Yazdi M, Carcopino C, Khademi Moghadam F, Smith MD, Trill A, Trefny MP, Hasanzadeh Kafshgari M, Hoch CC, Gaballa A, Alkotub B, Altomonte J, Pockley AG, Wagner E, Wollenberg B, Kobold S, Multhoff G, Bashiri Dezfouli A.   +17 more
europepmc   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

An Exploratory Study of Heat Shock Protein Changes in Women with Unexplained Infertility. [PDF]

Int J Mol Sci
Alhalwachi Z, Sathyapalan T, Butler AE, Atkin SL.   +3 more
europepmc   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle control. [PDF]

Elife
Moss T, Wooldredge A, Bhakta K, Cronin M, Gestwicki JE, Mukherjee S.   +5 more
europepmc   +1 more source

Delivery of HSP70 mRNA via exosomes ameliorates sleep deprivation-induced cognitive impairments in mice. [PDF]

Transl Psychiatry
Kang Z, Zhu G, Su C, Zhong X, Lin J, Lin Y.   +5 more
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

The role of the nucleus in the control of mitochondrial precursor proteins in yeast. [PDF]

Protein Sci
Ritzenhofen K, Rossi S, Mogk A, den Brave F.   +3 more
europepmc   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Heat Shock Proteins as Targets for Cancer Therapeutics. [PDF]

J Clin Med
Trikala A, Shen B, Bhardwaj S.
europepmc   +1 more source