Results 181 to 190 of about 21,325,054 (309)

Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link

The FEBS Journal, EarlyView.
Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello, Maria Cristiano, Ilaria Di Nardo, Ida Palumbo, Erika Piccolo, Rosario Oliva, Andrea Bosso, Aldo Donizetti, Eugenio Notomista, Elio Pizzo   +9 more
wiley   +1 more source

Construction of a Three-Dimensional Culture Model of HSV-1 Based on the Nano-Self-Assembling Peptide RADA16-I and Preliminary Exploration of the Relationship Between HSV-1 and Autophagy. [PDF]

Microorganisms
Hu Z, Xu YE, Zhang J, Luo X, Li JZ, Wang YT, Li HM, Sun X, Wang SY, Song H, Ao DS.   +10 more
europepmc   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Projected public health benefits of a hypothetical HSV-1 vaccine in the United States: A mathematical modeling analysis. [PDF]

Sci Adv
Naffeti BS, Ayoub HH, Johnston C, Abu-Raddad LJ.   +3 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Carbon monoxide-producing probiotic <i>Escherichia coli</i> attenuates HSV-1 skin disease. [PDF]

iScience
Vallejos OP, Hoppe-Elsholz G, Reyes-Bustos P, Tognarelli EI, Vázquez Y, Piña-Iturbe A, Pereira-Sánchez P, Vásquez-Herrera L, Bahamondes-Abrigo JP, Vergara-Espinoza VA, Quero FB, Campos-Gajardo S, Sepúlveda-Alfaro J, Acevedo-López J, Suazo ID, Silva PH, Caamaño E, Scaff V, Bassi F, Coronado-Arrázola I, Melo-González F, Mateluna A, Álvarez-Lobos M, Wozniak A, Kalergis AM, González PA, Bueno SM.   +26 more
europepmc   +1 more source

CD49a expression defines a metabolically robust, cytokine‐biased liver NK cell subset in rhesus macaques during lentivirus infection

Immunology &Cell Biology, EarlyView.
Liver‐resident NK cells (CD49a+ NK cells) in rhesus macaques display distinct activating receptor and metabolic markers enhanced phenotype compared with hepatic NK cell subsets (CD49a−) in the liver. These cells exhibit heightened cytokine polyfunctionality with restrained cytotoxic responses upon mitogen stimulation in comparison with CD49a− NK cell ...
Andrew Hudson, Melissa Xin Yu Wong, Michael Verdolin, R Keith Reeves, Cordelia Manickam   +4 more
wiley   +1 more source

Linker histone H1.2 inhibits HSV-1-induced IFN response via cGAS. [PDF]

mBio
Li S, Li C, Zhou F, Zhang Y, Li M, Xie B, Ning L, Lin X, Zhao B, Hong X, Yan D.   +10 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Development of an HSV-1 F strain BAC system using the synthetic platform. [PDF]

Virol Sin
Yin Q, Xiao H, Hu H, Li J, Wang M, Hu Z.
europepmc   +1 more source