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Erratum: Are Glucocorticoids Truly Effective in Improving the Clinical Prognosis of HSV-1 Encephalitis? [Corrigendum]. [PDF]
Infect Drug Resisteuropepmc +1 more source
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1998
Almost two centuries ago, long before they were identified as infectious agents, viruses were used for therapeutic applications. In 1798, Jenner discovered that persons inoculated with less pathogenic cowpox (cowpox virus) were protected from subsequent infection with deadly smallpox (variola virus) (1).
Cornel Fraefel +2 more
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Almost two centuries ago, long before they were identified as infectious agents, viruses were used for therapeutic applications. In 1798, Jenner discovered that persons inoculated with less pathogenic cowpox (cowpox virus) were protected from subsequent infection with deadly smallpox (variola virus) (1).
Cornel Fraefel +2 more
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Immune Control of HSV-1 Latency
Viral Immunology, 2005A hallmark of the herpes family of viruses is their ability to cause recurrent disease. Upon primary infection, Herpes Simplex virus (HSV) establishes a latent infection in sensory neurons that persists for the life of the individual. Reactivation of these latent viral genomes with virion formation is the source of virus for most HSV recurrent disease.
Vilma, Decman +3 more
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SUN2 Modulates the Propagation of HSV-1
Journal of Virology, 2022The large size of herpesviruses prevents them from travelling across the nuclear pores, and they instead egress across the two nuclear membranes, generating short-lived enveloped perinuclear virions. This poses a challenge as the perinuclear space is smaller than the virions.
Kendra Cruz-Palomar +5 more
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HSV-1 amplicon peptide display vector
Journal of Virological Methods, 2003There are significant uses for expressing foreign peptide epitopes in viral surface attachment proteins in terms of investigating viral targeting, biology, and immunology. HSV-1 attachment, followed by fusion and entry, is mediated in large part by the binding of viral surface glycoproteins to cell surface receptors, primarily through heparan sulfate ...
Spear MA +8 more
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Science Signaling, 2018
An HSV-1 enzyme represses innate immune responses by deamidating the cytosolic DNA sensor cGAS.
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An HSV-1 enzyme represses innate immune responses by deamidating the cytosolic DNA sensor cGAS.
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