Control of herpes simplex virus type 1 latency in human trigeminal ganglia [PDF]
Herpes simplex virus type 1 (HSV-1) is a double-stranded DNA virus that infects humans and, after a primary lytic infection, establishes lifelong latency in the sensory neurons of the trigeminal ganglia (TG).
Held, Kathrin
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Transversal/coronal sections from the whiskers area (A, B, G and H) and brain stem (E–F), longitudinal/sagittal sections from the trigeminal ganglia (C, D, I and J) from HSV-1 infected BN and SHR strains at 4dpi; stained for HSV-1 marker (green) (A–J ...
Ana Garcia-Diaz (2806306) +20 more
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HSV-1 pUL21 directly binds host proteins CERT and PP1, promoting CERT dephosphorylation.
(A) SILAC-labelled HEK293T cells were transfected with plasmids expressing GFP-tagged pUL21 or GFP alone. At 24 hours post-transfection the cells were lysed, subjected to immunoprecipitation (IP) using a GFP affinity resin, captured proteins were ...
Viv Connor (3175485) +17 more
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This study shows drying‐driven microstructural reorganization as a key origin of rate limitations in multi‐walled carbon nanotubes (MWCNT)‐based thick electrodes. By decoupling transport properties, the work reveals that rapid evaporation can amplify thickness‐dependent CNT agglomeration, generating coupled electronic and ionic bottlenecks. Importantly,
So Min Gong +8 more
wiley +1 more source
Herpes Simple Virus proctitis: a diagnostic dilemma between anal disorders
A 72-year-old man was referred to our surgical outpatient department because of severe anal pain, anal bleeding and itching for the last 5 days. Clinical examination revealed severe efflorescence with painful ulcers around the anus.
Athanasios Syllaios, Spyridon Davakis
doaj +1 more source
Anti-HSV-1 antibody level by BMI index among diabetic patients.
(Kruskal-Wallis Test; H = 82.57; p = 10−4) HSV IgG—IgG antibodies herpes simplex virus, BMI-body mass index, NTU—NovaTec Units.
Jakub Dworzański (7423370) +4 more
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HSV-1 inflammasome activation in THP-1 cells is dependent on NLRP3, ASC, and caspase-1.
A. THP-1 cells were stimulated overnight with PMA (100 ng/mL) and then incubated with HSV-1, nigericin and LPS (Ng+LPS), or media, as outlined in Materials and Methods, for 24 hours.
Andrew H. Karaba (2419798) +5 more
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An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones [PDF]
Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in
Heather M. Coleman +13 more
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Cenobamate use in super‐refractory status epilepticus: A report of three cases
Abstract Objectives Super‐refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited. Methods This retrospective case series reports the use of cenobamate as add‐on therapy in the management of three cases of ...
Marina Romozzi +11 more
wiley +1 more source
Analysis of the prevalence of STIs in Russia according to the federal laboratory network
Background. The incidence rate of sexually transmitted infections (STIs) in different countries has attracted the attention of specialists from all over the world.
Elena V. Vladimirova +4 more
doaj +1 more source

