Results 261 to 270 of about 191,153 (333)

Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases

open access: yesChemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Pharmacophore‐based virtual screening and molecular dynamics identified pentagalloylglucose and tannic acid as potent, non‐toxic neprilysin inhibitors. These natural compounds demonstrated strong binding affinity and stable interactions with the catalytic Zn2+ site, offering promising leads for cardiovascular drug development. ABSTRACT Neprilysin (NEP),
Chung‐Ting Kuo   +4 more
wiley   +1 more source

Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans

open access: yesImmunology &Cell Biology, Volume 104, Issue 2, Page 109-124, February 2026.
In this study, we characterize a distinct subpopulation of undifferentiated invariant natural killer T (iNKT) cells in the peripheral blood of healthy adults, which are characterized by CD38 expression in a resting state. This CD38+ subset closely resembles iNKT cells from cord blood and thymus, exhibiting a unique cytokine profile and alterations in ...
Christopher Menne   +13 more
wiley   +1 more source

The H4K20-mono-methyltransferase SETD8 promotes global accessibility of infecting herpes simplex virus genomes. [PDF]

open access: yesJ Virol
Arbuckle JH   +6 more
europepmc   +1 more source

Janus kinase and calcineurin‐inhibitor combination in anti‐MDA5 dermatomyositis: No significant survival benefit but reassuring safety profile

open access: yesJournal of Internal Medicine, Volume 299, Issue 2, Page 228-240, February 2026.
Abstract Objectives Anti‐MDA5 dermatomyositis (anti‐MDA5 DM) is the most severe subtype of dermatomyositis, due to its pulmonary involvement. Current treatment involves corticosteroids and immunosuppressants, but variability in responses exists. This study aims to evaluate the efficacy and safety of Janus kinase (JAK)– and calcineurin–inhibitor ...
Valentine Pagis   +47 more
wiley   +1 more source

Ischemic Stroke in Hypereosinophilic Syndrome: A Clinicopathologic Study of Two Cases

open access: yesNeuropathology, Volume 46, Issue 1, February 2026.
ABSTRACT Ischemic stroke is a rare complication of hypereosinophilic syndrome (HES). Manifestations of stroke in HES have been described in the radiologic literature; however the pathologic characterization of central nervous system (CNS) involvement in HES is limited.
Karina C. Martin   +3 more
wiley   +1 more source

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