Results 61 to 70 of about 120,788 (312)

Classification of Rice Leaf Diseases Using Support Vector Machine with HSV and GLCM-Based Feature Extraction

Journal of Applied Informatics and Computing
This study aims to classify rice leaf diseases using the Support Vector Machine (SVM) algorithm based on image processing and feature extraction. A total of 600 rice leaf images were collected, each representing one of five disease types: bacterial ...
Rizal Ramli, Evanita Evanita, Aditya Akbar Riadi   +2 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition

OncoImmunology, 2019
Immunotherapy with oncolytic herpes simplex virus-1 therapy offers an innovative, targeted, less-toxic approach for treating brain tumors. However, a major obstacle in maximizing oncolytic virotherapy is a lack of comprehensive understanding of the ...
Joshua D. Bernstock, Nunzio Vicario, Li Rong, Pablo A. Valdes, Bryan D. Choi, Jason A. Chen, Daniel DiToro, Diana S. Osorio, Kara Kachurak, Florian Gessler, James M. Johnston, T. Prescott Atkinson, Richard J. Whitley, Asim K. Bag, G. Yancey Gillespie, James M. Markert, Dragan Maric, Gregory K. Friedman   +17 more
doaj   +1 more source

HSV-2 infection dynamics from a single model simulation.

, 2018
(A) Total (summed across the whole simulation region) HSV-2 and infected epithelial cell counts. (B) Cytokine concentration. (C) CD4+ and CD8+ T cell densities. (D) Percentage of the modelled region damaged due to lesion development.
Catherine M. Byrne (5147228), Daniel Coombs (220678), Soren Gantt (632933)   +2 more
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

The role of herpes simplex virus infection in the etiology of head and neck cancer–a Mendelian randomization study

Frontiers in Immunology
IntroductionHead and neck cancer (HNC) is a complex disease, and multiple risk factors can lead to its progression. Observational studies indicated that herpes simplex virus (HSV) may be correlated with the risk of HNC.
Ming Yan, Ming Yan, Li-yuan Xiao, Martin Gosau, Ralf Smeets, Ralf Smeets, Hong-chao Feng, Simon Burg, Ling-ling Fu, Ling-ling Fu, Reinhard E. Friedrich   +10 more
doaj   +1 more source

HSV-1 infects human NK cells.

, 2019
(A) PBMCs were cultured with mock infected inoculum or inoculum infected with HSV-1 expressing GFP under different viral promoters (ICP47, ICP6 or gB as specified) for 1 day. Infection of NK cells (viable CD3–CD56+ cells) was determined by flow cytometry
Tiffany Ann Russell (6837791), Allison Abendroth (5155166), Megan Steain (5155169), Tessa Mollie Campbell (5155157), Brian Patrick McSharry (5155163), Barry Slobedman (5155160), David Carl Tscharke (6837794), Jarrod John Kennedy (6837797)   +7 more
core   +1 more source

HSV-1 activates inflammasomes in primary human macrophages.

, 2020
A and B. Primary human MDMs cultured without (M0 A) or with IFNγ (M1 B) were incubated with HSV-1 or media for 24 hours. Cell culture supernatants were collected and assayed for IL-18 (B represents the combination of two experiments).
Andrew H. Karaba (2419798), Guido Massaccesi (8496237), Sara Botto (210516), Alexis Figueroa (8496234), Andrea L. Cox (8496243), Victor R. DeFilippis (8496240)   +5 more
core   +1 more source

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer

Advanced Science, EarlyView.
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang, Chengyu Lu, Zhen Wang, Zhijian Cen, Yangshu Zhou, Danyi Li, Qi Xie, Bingbing Li, Shujing Guo, Zhijun Gan, Er‐ran Zhu, Jinbang Li, Aihetaimu Aimaier, Rui Mao, Weihao Qiu, Chenglong Zhao, Ying Tan, Xiaolin Liu, Huiting Ma, Tiansu Geng, Peiyue Wu, Huijun Du, Yu Wang, Yueping Liu, Li Liang   +24 more
wiley   +1 more source