Results 61 to 70 of about 117,409 (314)
Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response
Advanced Science, EarlyView.This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du +10 more
wiley +1 more source
Journal of Islamic International Medical CollegeObjective: To determine the seroprevalence of Herpes simplex virus among females of childbearing age. Study Design: Cross sectional study. Place and Duration of Study: Virology department, Armed Forces Institute of Pathology Rawalpindi, from 1July 2022
Faraz Ahmed
doaj +1 more source
HSV-replication defective based vector as vaccines against Rotavirus infections [PDF]
, 2011 Background: Rotaviruses (RVs) are the most important cause of acute gastroenteritis in humans and animals. These viruses cause diarrheal disease primarily in the young, but infection and disease in older children and adults can occur, resulting in more ...
Facciolo, Sabrina
core
, 2019 (A) PBMCs were cultured with mock infected inoculum or inoculum infected with HSV-1 expressing GFP under different viral promoters (ICP47, ICP6 or gB as specified) for 1 day. Infection of NK cells (viable CD3–CD56+ cells) was determined by flow cytometry
Tiffany Ann Russell (6837791) +7 more
core +1 more source
HSV-1 infection promotes the STING-NLRP3 interaction.
, 2020 (A, B) TPA-differentiated THP-1 macrophages were mock-infected or infected with HSV-1 (MOI = 1) for 4 h (A) or 2 h and 4 h (B). (C, D) HEK293T cells (C) and Hela cells (D) were co-transfected with pFlag-STING and pHA-NLRP3, and then infected with HSV-1 ...
Weijie Chen (1321836) +16 more
core +1 more source
, 2021 (A) Coomassie blue staining of density gradient purified HSV-1 L- and H-particles. Arrow indicates position of the VP5 major capsid protein that is present in H-particles but absent from L-particles.
Cliff Van Waesberghe (11768086) +4 more
core +1 more source
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention?
Frontiers in Pediatrics, 2016 We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high dose glucocorticoids were not able to reverse the multiple ...
E. Scott Halstead +3 more
doaj +1 more source
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
Journal of Applied Informatics and ComputingThis study aims to classify rice leaf diseases using the Support Vector Machine (SVM) algorithm based on image processing and feature extraction. A total of 600 rice leaf images were collected, each representing one of five disease types: bacterial ...
Rizal Ramli +2 more
doaj +1 more source