Results 71 to 80 of about 117,409 (314)

HSV-1 protein ICP27 interacted with MOV10 to antagonize MOV10 restriction of HSV-1 replication.

, 2022
(A) Left, volcano plot for the differences between protein levels in the MOV10 specific pulldown group and control pulldown group as analyzed by LC-MS/MS. Red dots represent candidate interacting proteins according to the selection criteria of p t-test).
Ze Xiang (12085909), Dongli Pan (2475040), Feiyang Ji (5393894), Xiyuan Yang (12085906), Zeyu Sun (2932719), Keyi Ren (9182103)   +5 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition

OncoImmunology, 2019
Immunotherapy with oncolytic herpes simplex virus-1 therapy offers an innovative, targeted, less-toxic approach for treating brain tumors. However, a major obstacle in maximizing oncolytic virotherapy is a lack of comprehensive understanding of the ...
Joshua D. Bernstock, Nunzio Vicario, Li Rong, Pablo A. Valdes, Bryan D. Choi, Jason A. Chen, Daniel DiToro, Diana S. Osorio, Kara Kachurak, Florian Gessler, James M. Johnston, T. Prescott Atkinson, Richard J. Whitley, Asim K. Bag, G. Yancey Gillespie, James M. Markert, Dragan Maric, Gregory K. Friedman   +17 more
doaj   +1 more source

HSV-2 infection dynamics from a single model simulation.

, 2018
(A) Total (summed across the whole simulation region) HSV-2 and infected epithelial cell counts. (B) Cytokine concentration. (C) CD4+ and CD8+ T cell densities. (D) Percentage of the modelled region damaged due to lesion development.
Catherine M. Byrne (5147228), Daniel Coombs (220678), Soren Gantt (632933)   +2 more
core   +1 more source

HSV-1 activates inflammasomes in primary human macrophages.

, 2020
A and B. Primary human MDMs cultured without (M0 A) or with IFNγ (M1 B) were incubated with HSV-1 or media for 24 hours. Cell culture supernatants were collected and assayed for IL-18 (B represents the combination of two experiments).
Andrew H. Karaba (2419798), Guido Massaccesi (8496237), Sara Botto (210516), Alexis Figueroa (8496234), Andrea L. Cox (8496243), Victor R. DeFilippis (8496240)   +5 more
core   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

The role of herpes simplex virus infection in the etiology of head and neck cancer–a Mendelian randomization study

Frontiers in Immunology
IntroductionHead and neck cancer (HNC) is a complex disease, and multiple risk factors can lead to its progression. Observational studies indicated that herpes simplex virus (HSV) may be correlated with the risk of HNC.
Ming Yan, Ming Yan, Li-yuan Xiao, Martin Gosau, Ralf Smeets, Ralf Smeets, Hong-chao Feng, Simon Burg, Ling-ling Fu, Ling-ling Fu, Reinhard E. Friedrich   +10 more
doaj   +1 more source

HSV-2 replication in the cornea of C57Bl/6J mice.

, 2018
(A) Schematic representation of the murine ocular HSV-2 infection model. Both corneas of anesthetized mice were scarified. Virus was placed on the eyes using 105 pfu/eye. Ocular swabs were taken at the indicated time points post infection (p.i.). Animals
Michael Spohn (3163416), Maike Voges (154488), Martha M. Eibl (772117), Julia S. Czechowicz (5598296), Joachim Hauber (140870), Claus-Henning Nagel (309485)   +5 more
core   +1 more source

Interpretation of the 2024 BASHH & RCOG UK guideline on HSV management in pregnancy: key recommendations and comparison with Chinese clinical practice

Pifu-xingbing zhenliaoxue zazhi
Herpes simplex virus (HSV) types 1 and 2 pose significant health risks during pregnancy, impacting both maternal and neonatal outcomes. The 2024 joint guideline from the British Association for Sexual Health and HIV (BASHH) and the Royal College of ...
FERREIRA Esmeraldito, CHEN Zhaoqi, KE Wujian   +2 more
doaj   +1 more source

Establishment of multiplex Real-Time PCR assay for simultaneous detection of Herpes simplex virus and Varicella-zoster virus

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2015
The herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV) can cause life-threatening infections of the central nervous system and lead to severe disease in newborns and immunosuppressed patients.
Lao Duc Thuan, Truong Kim Phuong, Ho Thi Thanh Thuy, Le Huyen Ai Thuy   +3 more
doaj