Results 51 to 60 of about 24,867 (223)

The restricted mean survival time as a replacement for the hazard ratio and the number needed to treat in long‐term studies

ESC Heart Failure, 2021
Aims We applied the restricted mean survival time (RMST) to analyse the survival data reported in the PARADIGM‐HT trial in which sacubitril + valsartan was studied in comparison with enalapril in patients with heart failure.
Andrea Messori, Laura Bartoli, Sabrina Trippoli   +2 more
doaj   +1 more source

Variability in UK Body Donation Information: A Comparison of Bequeathal Information and Consent Forms With Recommendations for Standardization

Clinical Anatomy, EarlyView.
ABSTRACT The use of human donor bodies for anatomical examination in the United Kingdom is regulated by the Human Tissue Authority (England, Wales, and Northern Ireland) and His Majesty's Inspector of Anatomy for Scotland. This study aimed to assess the variability of information provided to body donors and the associated consent forms across UK ...
Janet A. C. Philp, Kat A. Sanders
wiley   +1 more source

Best Practices and Gaps in Current Regulatory and Health Technology Assessment Real-World Evidence Policies for Medicines and Medical Devices: Current State of Play and Next Steps. [PDF]

Clin Transl Sci
ABSTRACT Real‐world data (RWD) offers a valuable opportunity to access vast information that can drive research and generate real‐world evidence (RWE), offering insights into the actual delivery of care and patient outcomes beyond the limitations of traditional clinical trials.
Cresswell K, Claire R, Issa L, Kubehl L, Bilal O, Purcell R, Clemente A, Wested J, Jensen LG, Sasane M, Peeters R, Shinkins B, Colvin H.   +12 more
europepmc   +2 more sources

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Brief Analysis of the Validation of Analytical Methods for Radiopharmaceuticals

Journal of Isotopes
Method validation is an important step to ensure the accuracy and reliability of analytical method，and is the basis for ensuring the controllable quality of drugs.
Mengyi CHEN, Weihua CHENG, Hongyu LI
doaj   +1 more source

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 10

Journal of Comparative Effectiveness Research, 2022
In this latest update we discuss the transportability of comparative effectiveness evidence across countries. We highlight results of a survey indicating that European HTA agencies are reluctant to accept real-world data from other countries, review ...
Alex Simpson, Sreeram V Ramagopalan
doaj   +1 more source

Evaluating Transcriptomic Biomarkers for rHuEPO Detection: Assessing the Impact of Exercise and Altitude Exposure

Drug Testing and Analysis, EarlyView.
A two‐stage transcriptomic filter comparing rHuEPO, exercise and altitude responses reduced 153 candidate genes to 50 that were unaffected by physiological stimuli. These retained transcripts offer focused biomarker leads to strengthen antidoping detection of rHuEPO.
Daria Obratov, Shaun Sutehall, Longhua Liu, Zhao Zhongying, Yannis Pitsiladis   +4 more
wiley   +1 more source

Evaluation du système de surveillance de l’hypertension artérielle et du diabète dans le cadre de l’approche WHOPEN dans le District Sanitaire de Golfe, Togo, 2023

Journal of Interventional Epidemiology and Public Health
Introduction: L’approche World Health Organization Package of Essential Nonconmmunicable (WHOPEN)permet la prévention, la détection précoce et la prise en charge de l’hypertension artérielle (HTA) et diabète.
Bassotom Lakougnon, Wemboo Afiwa Halatoko, Ablaga Dzidzova Amenyido Nyameko, Rébecca Kinde, Aboudramane Lambonkale, Koffi Akolly, Christelle Somtinda Nikiema, Latifou Assikpa, Thomas Charly Nyama, Didier Koumavi Ekouevi   +9 more
doaj   +1 more source

HTA AND VALUE - A COMMENTARY [PDF]

International Journal of Technology Assessment in Health Care, 2013
There is an expectation that the value of a new technology will be considered by decision makers in determining whether to provide subsidy. What constitutes the elements of value and how these may be weighted is not transparent, however, and further work needs to be done to determine the circumstances and mechanisms of their application.
openaire   +3 more sources

A Commentary on “Comparing Operationalizations of Eating Disorder Recovery Using a Comprehensive Lens: Physical, Behavioral, and Cognitive Domains” by Bardone‐Cone et al.

International Journal of Eating Disorders, EarlyView.
ABSTRACT Defining recovery in eating disorders remains a major challenge due to the absence of standardized, empirically validated criteria. Bardone‐Cone et al. (2025) address this gap by testing multidimensional, transdiagnostic recovery criteria spanning physical, behavioral, and cognitive domains.
Charlotte Bovenberg, Suman Ambwani, Valentina Cardi, Janet Treasure   +3 more
wiley   +1 more source