Results 91 to 100 of about 22,246,700 (213)
Perceptions of donor screening—Do I always need to tell the truth?
Abstract Background The Donor Health Assessment Questionnaire (DHQ) is fundamental to blood safety. We describe attitudes towards truthfulness among first‐time donors who tested positive for transfusion transmissible infections and those who did not.
Sheila F. O'Brien +2 more
wiley +1 more source
Human T lymphotropic virus 1 (HTLV-1) is a public health issue for most countries and imposes important consequences on patients' health and socioeconomic status. Brazil is one of the global leaders of the public health response to these viruses.
Angelica Espinosa Miranda +7 more
doaj +1 more source
What's new? Adult T‐cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T‐cell leukemia virus type 1 (HTLV‐1). The authors comprehensively analyzed the epidemiological and clinical features of ATL over a 30‐year period in French Guiana, a region with high HTLV‐1 endemicity and a multiethnic population.
Jill‐Léa Ramassamy +16 more
wiley +1 more source
Immunological characteristics of Spanish IDUs infected with HTLV-2 and HIV-1 [PDF]
Background HTLV-2 infection has been detected in injecting drug users (IDUs) in Spain, who often are coinfected with HCV and HIV-1. It has been reported that HCV infection increases the immune activation of HIV-1-infected patients. Our objective was to analyze how HTLV-2 infection affects T-cell activation and other immunological parameters such as ...
Moreno Santiago +6 more
openaire +2 more sources
HIV-1/HTLV Co-Infection: a Survey of Molecular Basis with Clinical Studies [PDF]
Human immunodeficiency virus type-1 (HIV–1) and human T-cell leukemia virus (HIV-1/HTLV) co-infection is a serious health problem worldwide, especially in endemic areas and vulnerable subjects like intravenous drug abusers.
Marzieh Saberi, Ashraf Tavanaii sani
doaj +1 more source
Abstract This study aims to explore the mechanism of action of the Bromodomain‐containing protein 4 (BRD4) inhibitor GNE‐987 in the treatment of pediatric T‐cell Acute Lymphoblastic Leukemia (T‐ALL), focusing on its effect in inhibiting T‐ALL cell proliferation by activating the HLA Complex P5 (HCP5) Super‐enhancer.
Xu Sang +6 more
wiley +1 more source
Regulation of AP-1 activity by the HTLV-2 APH-2 protein [PDF]
In contrast to HTLV-1 which causes adult T-cell leukemia/lymphoma (ATL/ATLL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), the role of HTLV-2 in human disease is less clearly defined but infection is associated with rare lympho-proliferative and neurological disorders.
Sheehy Noreen +2 more
openaire +2 more sources
A Fashi Lymphoproliferative Phenotype Reveals Non-Apoptotic Fas Signaling in HTLV-1-Associated Neuroinflammation [PDF]
Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the ...
Anne Mieke Vandamme +18 more
core +1 more source
Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li +13 more
wiley +1 more source

