Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, Volume 59, Issue 9, September 2026.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
HTLV-1 prevalence by age and gender in seven remote central Australian communities, 2014–18.
, 2021 HTLV-1 prevalence by age and gender in seven remote central Australian communities, 2014–18.
Antoine Gessain (31917) +7 more
core +1 more source
Asian Journal of Transfusion Science, 2015 Background and Objectives: Human T-cell lymphotropic virus type-I (HTLV-I) infection is considered as a public health challenge in endemic areas. The virus is associated with severe diseases, such as adult T-cell leukemia/lymphoma, and HTLV-I-associated ...
Mahtab Maghsudlu +2 more
doaj +1 more source
HTLV-1 and HIV/HTLV-1 prevalence distribution by sex and age class.
, 2022 The figure shows the overall prevalence of infection by age group and the prevalence of infection by sex: A) In the HIV-1/HTLV-1 coinfected population; B) In the general population at the same place.
Jeanne Sica (686072) +10 more
core +1 more source
HTLV-I/II and blood donors: determinants associated with seropositivity in a low risk population
Revista de Saúde Pública, 2003 OBJECTIVE: Blood donors in Brazil have been routinely screened for HTLV-I/II since 1993. A study was performed to estimate the prevalence of HTLV-I/II infection in a low risk population and to better understand determinants associated with seropositivity.
Soares Bernadette Catalan +2 more
doaj +3 more sources
Molecular Cancer, 2010 Background Human T-cell leukemia virus type I (HTLV-I) has efficiently adapted to its host and establishes a persistent infection characterized by low levels of viral gene expression and slow proliferation of HTLV-I infected cells over decades.
Bai XueTao +3 more
doaj +1 more source
Comparison of four HTLV-I and HTLV-I + II ELISAs
, 1999 BACKGROUND: Various countries require blood donor screening using assays applying specific HTLV-I and HTLV-II antigens. We evaluated the sensitivity and specificity of 4 anti-HTLV-I + II ELISAs (Abbott, Murex, Organon Teknika and Ortho). METHODS: Panel A
H. Vrielink +11 more
core +1 more source
Assessment of HTLV-I proviral load, HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection [PDF]
Iranian Journal of Basic Medical Sciences, 2014 Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on
Hossein Rahimi +4 more
doaj
The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases
Frontiers in Microbiology, 2012 Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis in small subsets of HTLV-1-carriers.
Mari eKannagi +4 more
doaj +1 more source
Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations. [PDF]
Microbiol Spectr, 2023 Kuramitsu M +28 more
europepmc +1 more source