Results 1 to 10 of about 21,757,128 (220)

Targeted Interventions in HAM/TSP: Emerging Therapies and Future Directions - A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aim Human T‐Lymphotropic virus type 1 (HTLV‐1) infection can lead to HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neurological disease characterized by progressive lower limb spasticity and autonomic dysfunction.
Rezaei MM, Nia MK, Rouzbahani KA, Kazemi M, Hosori NA, Norouzi M, Sotoudegan F, Eslami N, Ariamand N, Shahnavaz V, Letafati A, Mozhgani SH.   +11 more
europepmc   +2 more sources

Molecular Evidence of Human T‑Cell Leukemia Virus Type 1 Transmission by Needlestick Injury in Healthcare Workers. [PDF]

J Med Virol
ABSTRACT Human T‑cell leukemia virus type 1 (HTLV‑1) is a retrovirus that spreads primarily through cell‐to‐cell transmission. Occupational transmission of HTLV‐1 by needlestick injury is considered exceedingly rare, with no reported molecularly confirmed cases.
Tokunaga M, Kuramitsu M, Saito M, Yoshimori M, Odawara J, Ito Y, Nakamura H, Sagara Y, Ishii M, Nojiri N, Yoshida-Furihata H, Kuribayashi W, Mizukami T, Miura K, Utsunomiya A.   +14 more
europepmc   +2 more sources

Utility of Flow Cytometry for Prognostic Prediction in Adult T-Cell Leukemia/Lymphoma. [PDF]

EJHaem
ABSTRACT Introduction Adult T‐cell leukemia/lymphoma (ATL) exhibits marked clinical heterogeneity; however, current classification primarily rely on morphology and laboratory findings and require further advancement. This study aimed to evaluate the roles of human T‐lymphotropic virus type 1 (HTLV‐1)–infected cell (CD4‐positive T cell) analysis system ...
Fuji S, Tokunaga M, Cook L, Utsunomiya A, Makiyama J, Suehiro Y, Koh KR, Nakashima M, Yamano Y, Uchimaru K.   +9 more
europepmc   +2 more sources

Chemiluminescence Immunoassay to Detect Anti‐HTLV‐I Antibodies [PDF]

Japanese Journal of Cancer Research, 1993
A fully automated chemiluminescence immunoassay was developed for the detection of antibodies to HTLV‐I. We used partially purified viral antigens coated on small polystyrene beads together with acridinium ester‐labeled anti‐human immunoglobulin G mouse immunoglobulin G in this method.
Kamihira, Shimeru, Nakashima, Shigehiro, Saitoh, Shin, Kawamoto, Michiko, Kawashima, Yumiko, Shimamoto, Mitoshi   +5 more
openaire   +2 more sources

Prevalence of HTLV-I Antibody in Pulmonary Cryptococcosis.

The Tohoku Journal of Experimental Medicine, 1992
A retrospective study was done to determine the prevalence of anti-HTLV-I antibodies in patients with pulmonary cryptococcosis. None of the 19 patients with pulmonary cryptococcosis had underlying immunodeficiency. Anti-HTLV-I antibody was present in 6 (32%) of 19 patients with pulmonary cryptococcosis, a significantly higher prevalence than found in ...
KOHNO, SHIGERU, KOGA, HIRONOBU, KAKU, MITSUO, YASUOKA, AKIRA, MAESAKI, SHIGEFUMI, TANAKA, KEN-ICHI, MITSUTAKE, KOTARO, MATSUDA, HARUKO, ARAKI, JUN, HARA, KOHEI   +9 more
openaire   +3 more sources

Anti-HTLV-I antibody and blood transfusion

Journal of Japanese Society for Dialysis Therapy, 1989
透析 (HD) 患者527名 (1988年1月) の血清中の抗HTLV-I抗体をゼラチン粒子凝集法 (particle agglutination test; PA法) およびWestern blotting (WB) 法にて測定し, 1984年5月332名, 1985年5月407名の結果と比較した. また, 1984年, 1985年, 1988年のPA陽性者の推移も合わせて検討した. 1986年11月より日本赤十字社にて抗HTLV-I抗体のスクリーニング検査が施行された. そこで, スクリーニング検査開始前, 後の抗体陽転者についても検討した. その結果,1.
Kaoru Igarashi, Kazunori Wakasugi, Shingo Yamane, Masaaki Sasaki, Kazuyoshi Tominaga, Takuo Nobuto, Nakanobu Azuma, Takao Matsugane, Mitsuru Suzuki   +8 more
openaire   +3 more sources

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

HTLV screening and confirmatory testing among blood donors in São Paulo: A cross‐sectional study

Transfusion Medicine, EarlyView.
Abstract Introduction Human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) are transfusion‐transmissible retroviruses associated with severe diseases, and blood donor screening is mandatory in Brazil. Increasing HTLV‐related discard rates at our institution prompted this study to determine the prevalence and incidence of HTLV‐1/2 and to investigate
Suzete C. Ferreira, Anna S. Nishyia, Jerenice E. Ferreira, Claudia Di Lorenzo Oliveira, Cesar de Almeida‐Neto, Tila Fanciani, Katia C. Dantas, Juliana Derriga, Silvia Petrossi Gallo Polato, Nanci Salles, Vanderson Rocha, Alfredo Mendrone‐Junior   +11 more
wiley   +1 more source

Detection of anti-HTLV-I Tax antibodies in HTLV-I enzyme-linked immunosorbent assay-negative individuals [PDF]

Blood, 1989
Abstract The HTLV-I tax gene protein (Tax) is not packaged within the mature viral particle from which the proteins for the commercially available enzyme-linked immunosorbent assay (ELISA) are derived. Screening of 162 individuals within a cohort of white intravenous (IV) drug abusers, previously identified as having an increased ...
G D, Ehrlich, J B, Glaser, M A, Abbott, D J, Slamon, D, Keith, M, Sliwkowski, J, Brandis, E, Keitelman, Y, Teramoto, L, Papsidero   +9 more
openaire   +2 more sources

Budget impact of implementing universal Plasmodium NAT screening in the blood transfusion system in the US

Transfusion, EarlyView.
Abstract Background Blood donor deferral for malaria risk relies exclusively on responses to self‐reported questionnaires. This study evaluated the economic impact of introducing Plasmodium nucleic acid testing (NAT) as a universal screening strategy in the United States.
Cristina Coll‐Ortega, Elisabet Viayna, Jiani Zhou, Susan L. Stramer   +3 more
wiley   +1 more source