Results 51 to 60 of about 21,821,162 (213)

Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2605-2612, October 2026.
ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora, Chen‐Lin Hsieh, Sanne Schoffelen, Johnny Arnsdorf, Eric A. Toth, Abdul S. Yunus, Thomas E. Cleveland IV, Sara Petersen Bjørn, Mina Ying Min Wu, Noel G. McElvaney, Bjørn Gunnar Rude Voldborg, Thomas R. Fuerst, Nathan E. Lewis   +12 more
wiley   +1 more source

Functional Loss of the HTLV-I Tax Protein Encoded by Variant Proviruses in Infected Individuals. [PDF]

, 1998
Accumulating evidence has indicated the presence of HTLV-I quasispecies in infected individuals. To elucidate their biological consequences, we amplified the whole Tax open reading frame (ORF) of HTLV-I proviruses by nested PCR from six infected ...
Yamashita-Futsuki, Izumi, Roy, Bhabeshchandra, Katamine, Shigeru, Mizokami, Akinari, Moriuchi, Ryozo   +4 more
core  

HIV and HTLV-I Infections in the Americas

Medicine, 1989
With over 143,000 cases of AIDS reported to the World Health Organization from 145 countries and with an estimated 5 to 10 million people worldwide infected with HIV, AIDS has become firmly established as a global pandemic. In the region of the Americas over 100,862 cases of AIDS have been reported with indigenous transmission documented in 45 to 46 ...
T C, Quinn, F R, Zacarias, R K, St John
openaire   +2 more sources

Serologic Prevalence of Human T-Lymphotropic Virus (HTLV) among major Thalassemic Patients in Kermanshah 2010 [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2011
Introduction: Transfusion-transmitted infections (TTI) continue to be a major challenge for Blood transfusion organizations in the world and multi- transfused patients (MTPs) are at higher risk of infection. HTLV-1 is a retrovirus that easily transmitted
Keighobad Ghadiri, Amir Hossein Hashemian, Mansour Rezaei, Mehrdad Payandeh, Mohammad Erfan Zare   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, Volume 20, Issue 9, Page 2296-2322, September 2026.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Molecular characterization of Human T-cell Lymphotropic Viruses 1 and 2 (HTLV-1 and HTLV-2) in samples from blood donation candidates in the state of Pará, Brazilian Amazon

Brazilian Journal of Infectious Diseases
The Human T-Lymphotropic Virus (HTLV) is a retrovirus belonging to the Retroviridae family and the Deltaretrovirus genus, which has a tropism for T lymphocytes.
Carolina Alcântara Maneschy, Patricia Santos Lobo, Carlos Eduardo de Melo Amaral, Katarine Antonia dos Santos Barile, Jairo Augusto Americo de Castro, Rodrigo Vellasco Duarte Silvestre, Felipe Bonfim Freitas, Luana Silva Soares, Sylvia Fátima Santos Guerra   +8 more
doaj   +1 more source

Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology Os Vírus T-Linfotrópicos Humanos tipo I (HTLV-I) e tipo II (HTLV-II) na Guiana Francesa: epidemiologia clínica e molecular

Cadernos de Saúde Pública, 2003
We review here the epidemiological studies performed by our group on human retrovirus HTLV-I and HTLV-II infections and the associated diseases in French Guiana since 1984.
Mirdad Kazanji, Antoine Gessain
doaj   +1 more source

Impact of COVID-19 Pandemic on Seroprevalence of HIV, HBV, HCV and HTLV I-II in a Blood Bank in Medellín, Colombia, 2019–2022

Tropical Medicine and Infectious Disease, 2023
The objective of this research was to analyze the impact of the COVID-19 pandemic on seroprevalence of HIV, HBV, HCV and HTLV I-II in donors from a blood bank in Medellin, Colombia, 2019–2022. A cross-sectional analytical study was carried out with three
Jaiberth Antonio Cardona-Arias, Luis Felipe Higuita-Gutiérrez   +1 more
doaj   +1 more source

PREVALENCE OF ANTI-HTLV-I/II IN SLOVENIAN BLOOD DONORS AND THEIMPACT ON BLOOD SCREENING

Zdravniški Vestnik, 2008
BACKGROUND Human T-limphotropic viruses type I and II are retroviruses. People infected withHTLV-I/II are usually asymptomatic, lifelong antibodies carriers. Transfusion of blood components is one of the modes of virus transmissions.
Petra Jovanovič, Snežana Levičnik Stezinar   +1 more
doaj  

Evaluation of QuantiFERON-TB Gold for the Diagnosis of Mycobacterium tuberculosis Infection in HTLV-1-Infected Patients

Viruses
Human T-cell leukemia virus type 1 (HTLV-1) is associated with an increased risk of tuberculosis (TB). This study aimed to evaluate the performance of the QuantiFERON-TB Gold (QFT) test for the diagnosis of Mycobacterium tuberculosis (MTB) infection in ...
Luana Leandro Gois, Natália Barbosa Carvalho, Fred Luciano Neves Santos, Carlos Gustavo Regis-Silva, Thainá Gonçalves Tolentino Figueiredo, Bernardo Galvão-Castro, Edgar Marcelino Carvalho, Maria Fernanda Rios Grassi   +7 more
doaj   +1 more source