Results 21 to 30 of about 20,286 (181)
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, EarlyView.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2004 This study aimed at implementing a Nested-polymerase chain reaction (Nested-PCR) for the molecular diagnosis of human T-cell lymphotropic virus type I/II (HTLV-I and HTLV-II) infections in peripheral blood mononuclear cells of infected subjects in ...
Sandra Gallego +4 more
doaj +1 more source
Immunology, EarlyView.During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu +24 more
wiley +1 more source
Revista Brasileira de Ginecologia e Obstetrícia, 2005 OBJETIVOS: avaliar a prevalência, características epidemiológicas (idade e procedência) e a taxa de transmissão vertical da infecção pelo HTLV I/II em gestantes submetidas à triagem pré-natal de acordo com o Programa de Proteção à Gestante do Estado de ...
Ernesto Antonio Figueiró-Filho +5 more
doaj +1 more source
Journal of Periodontal Research, EarlyView.The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag +6 more
wiley +1 more source
Brazilian Journal of Infectious Diseases, 2011 Objective: To compare the clinical characteristics and outcomes of HIV-1-HTLV-1 coinfected patients, in Bahia, Brazil. Methods: Retrospective, comparative study. Results: Among a total of 123 consecutive HIV infected patients, 20 men (20.6%) and 6 women (
C. Brites +7 more
doaj +1 more source
HTLV screening and confirmatory testing among blood donors in São Paulo: A cross‐sectional study
Transfusion Medicine, EarlyView.Abstract Introduction Human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) are transfusion‐transmissible retroviruses associated with severe diseases, and blood donor screening is mandatory in Brazil. Increasing HTLV‐related discard rates at our institution prompted this study to determine the prevalence and incidence of HTLV‐1/2 and to investigate
Suzete C. Ferreira +11 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1998 The occurrence of HTLV-I/II and HIV-1 coinfections have been shown to be frequent, probably in consequence of their similar modes of transmission. This paper presents the prevalence of coinfection of HTLV among HIV-1 infected and AIDS patients in Belém ...
Vallinoto ACR +7 more
doaj
Arquivos de Neuro-Psiquiatria, 2006 HTLV-I and HTLV-II are endemic in some areas of Brazil, where an associated disease, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) have been diagnosed in significant number of infected individuals. Tuberculosis has been demonstrated
Marcio Menna-Barreto, Denise C. Machado
doaj +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.We found that SOCS3 deficiency activates STAT3 to enhance glioma stem cell (GSC) stemness and survival. We demonstrated that IL‐6 rescues STAT3 signaling and reverses SOCS3‐mediated tumor suppression. We revealed that SOCS3‐low GSCs exhibit enriched p53 and JAK‐STAT pathway activity. This study provides new mechanistic insights into SOCS3‐STAT3 axis in
Jingtao Wang +5 more
wiley +1 more source