Results 61 to 70 of about 45,445 (214)

HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment

Viruses, 2017
Going back to their discovery in the early 1980s, both the Human T-cell Leukemia virus type-1 (HTLV-1) and the Human Immunodeficiency Virus type-1 (HIV-1) greatly fascinated the virology scene, not only because they were the first human retroviruses ...
Nicolas Futsch, R. Mahieux, H. Dutartre
semanticscholar   +1 more source

Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4

Retrovirology, 2009
Background Human T-lymphotropic virus type 4 (HTLV-4) is a new deltaretrovirus recently identified in a primate hunter in Cameroon. Limited sequence analysis previously showed that HTLV-4 may be distinct from HTLV-1, HTLV-2, and HTLV-3, and their simian ...
Wolfe Nathan D, Pryor Kendle N, Marriott Susan J, Katzourakis Aris, Gray Rebecca R, Jia Hongwei, Qari Shoukat H, Salemi Marco, Switzer William M, Burke Donald S, Folks Thomas M, Heneine Walid   +11 more
doaj   +1 more source

Flow cytometric assessment of T‐cell receptor β‐chain constant region 1/2 skewing as a surrogate marker for clonality in human T‐cell leukaemia virus type‐1–infected cells

British Journal of Haematology, EarlyView.
Summary Estimating T‐cell clonality within human T‐cell leukaemia virus type 1 (HTLV‐1)–infected cell populations may aid risk assessment and diagnosis of adult T‐cell leukaemia/lymphoma (ATL). However, direct assessment of HTLV‐1 integration‐site clonality requires genetic analyses that are costly and labour‐intensive.
Koji Jimbo, Aileen G. Rowan, Momoko Usui, Kako Suzuki, Makoto Yamagishi, Junya Makiyama, Lucy B. M. Cook, Yoshihisa Yamano, Kaoru Uchimaru, Yasuhito Nannya, Shigeo Fuji   +10 more
wiley   +1 more source

The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis

bioRxiv, 2018
Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact on the structure
A. Melamed, Hiroko Yaguchi, Michi Miura, Aviva D. Witkover, T. Fitzgerald, E. Birney, C. Bangham   +6 more
semanticscholar   +1 more source

HTLV-1/2 proviral load by sex and age among rural population in Gabon, central Africa.

, 2018
Rectangle: Average magnitude of HTLV1/2 proviral load; Line: Median proviral load; Bar: Standard deviation. HTLV-1/2 proviral load was measured by a multiplex real-time PCR assay involving a molecular beacon probe for simultaneous detection ...
Maria Makuwa (131491), Guillaume Besson (313049), Melanie Caron (2558596), Eric Leroy (264004), Dieudonne Nkoghe (3404600), Cindy Padilla (201518), Mirdad Kazanji (136517)   +6 more
core   +1 more source

Caracterização molecular do HTLV-1 em pacientes com paraparesia espástica tropical/mielopatia associada ao HTLV-1 em Belém, Pará Molecular characterization of HTLV-1 among patients with tropical spastic paraparesis/HTLV-1 associated myelopathy in Belém, Pará

Revista da Sociedade Brasileira de Medicina Tropical, 2006
O presente estudo avaliou a ocorrência da infecção pelo HTLV-1 e seus subtipos em amostras de sangue de pacientes com diagnóstico clínico de paraparesia espástica tropical/mielopatia associada ao Htlv-1.
Lucinda A. Souza, Ivina G.L. Lopes, Eduardo Leitão Maia, Vânia N. Azevedo, Luiz Fernando A. Machado, Marluísa O.G. Ishak, Ricardo Ishak, Antonio Carlos R. Vallinoto   +7 more
doaj   +1 more source

Distinct Clinical Features of Multiple Myeloma With t(11;14): A Post Hoc Analysis of JSH‐MM‐15 Study

Cancer Science, EarlyView.
t(11;14)‐positive MM is a clinically distinct subgroup characterized by intermediate prognostic risk, modest response depth, and treatment‐dependent outcomes. ABSTRACT t(11;14) (q13;q32) occurs in approximately 15%–25% of multiple myeloma (MM) cases and has traditionally been regarded as a standard cytogenetic risk factor.
Taku Tsukamoto, Yuji Shimura, Shinsuke Mizutani, Takahiro Fujino, Haruya Okamoto, Mitsuhiro Itagaki, Hiroshi Handa, Takayuki Shimizu, Morio Sawamura, Tadao Ishida, Satoru Kosugi, Shuichi Ota, Makoto Yoshimitsu, Yutaka Shimazu, Isamu Sugiura, Hirohiko Shibayama, Shin‐ichi Fuchida, Hiroyuki Takamatsu, Akiko M. Saito, Hitoshi Kiyoi, Koichi Akashi, Itaru Matsumura, Akifumi Takaori‐Kondo, Junya Kuroda, Shinsuke Iida   +24 more
wiley   +1 more source

HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil

PLoS ONE, 2017
Background Salvador is the city with the highest number of HTLV-1 infected individuals in Brazil, yet the main route of HTLV-1 transmission is unknown. Objective To investigate the association of syphilis infection as a proxy for sexual transmission of ...
David Nunes, N. Boa-Sorte, M. F. Grassi, G. Taylor, M. Teixeira, Maurício Lima Barreto, I. Dourado, B. Galvão-Castro   +7 more
semanticscholar   +1 more source

Trends in the prevalence and distribution of HTLV-1 and HTLV-2 infections in Spain

Virology Journal, 2012
Background Although most HTLV infections in Spain have been found in native intravenous drug users carrying HTLV-2, the large immigration flows from Latin America and Sub-Saharan Africa in recent years may have changed the prevalence and distribution of ...
Treviño Ana, Aguilera Antonio, Caballero Estrella, Benito Rafael, Parra Patricia, Eiros Jose M, Hernandez Araceli, Calderón Enrique, Rodríguez Manuel, Torres Alvaro, García Juan, Ramos Jose, Roc Lourdes, Marcaida Goitzane, Rodríguez Carmen, Trigo Matilde, Gomez Cesar, de Lejarazu Raul, de Mendoza Carmen, Soriano Vincent   +19 more
doaj   +1 more source

Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP

Frontiers in Microbiology, 2017
Human T cell lymphotropic virus type 1 (HTLV-1) infection can lead to development of adult T cell leukemia/lymphoma (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a subset of infected subjects.
Yoshimi Enose-Akahata, A. Vellucci, S. Jacobson   +2 more
semanticscholar   +1 more source