Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
Enhancing toxicological interpretation and reporting of <i>in vitro</i> high-throughput screening data. [PDF]
Hill BN +5 more
europepmc +1 more source
Upscaling Genotyping by Amplicon Sequencing With GBAS‐GUI
ABSTRACT Genotyping by amplicon sequencing (GBAS) is a relatively low‐cost approach for generating genotypic data compared with established genomic methods, making it highly scalable and particularly suitable for large‐scale genetic monitoring projects.
Sebastian Sonnenberg +8 more
wiley +1 more source
HTS-Oracle X: AI-Guided Prospective Discovery of Small Molecule Immune Checkpoint Binders. [PDF]
Abdel-Rahman SA, Gabr M.
europepmc +1 more source
The Chaetocerosphere: Chaetoceros Species and Associated Prokaryotes in a Coastal Area
Chaetoceros species maintain recurrent distinct prokaryotic assemblages in their phycosphere. Alphaproteobacteria, Bacteroidetes and Archaea Thermoplasmata and Marine Group II are the most represented in the phycosphere. Bipartite networks highlight strong links between the diatom and specific prokaryotic taxa, especially the chain‐forming species ...
Anna Chiara Trano +2 more
wiley +1 more source
Multi-omics mapping of PSC genetic risk to a high TWAS-active JAML+ lipid-associated macrophage program: bridging single-cell heterogeneity, spatial fibrotic niches, and machine learning selection. [PDF]
Du Z +5 more
europepmc +1 more source
ABSTRACT Introduction Preeclampsia is a major contributor to maternal and perinatal morbidity. First‐trimester predictive models for preterm preeclampsia have better efficacy than history‐based screening for prevention of this adverse pregnancy outcome.
Ailsa Borbolla Foster +7 more
wiley +1 more source
Characterization of yam virus X isolates from Dioscorea trifida in Brazil. [PDF]
Araújo CPFS +4 more
europepmc +1 more source
Civic ecosystem responses to compound crises: evidence from Syria
Abstract Compound crises have attracted growing interest from scholars and policymakers in recent years. Little attention, however, has been directed to the social relations that emerge from and respond to such phenomena. This paper closes the gap by investigating the emergence, impact, and limitations of the civic ecosystem that responded to the ...
Munzer Alkhalil +6 more
wiley +1 more source

