Results 181 to 190 of about 75,530 (296)

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources

Acknowledgement to reviewers

HTS Teologiese Studies/Theological Studies
Editorial Office
doaj   +1 more source

An Engineered Glove for the Objective Assessment of Hand Dexterity in Patients With Systemic Sclerosis. [PDF]

ACR Open Rheumatol
Sulli A, Hysa E, Clini P, Gotelli E, Vojinovic T, Pizzorni C, Jaffal A, Paolino S, Campitiello R, Smith V, Cutolo M.   +10 more
europepmc   +1 more source

Genomic Medicine Sweden: Advancing precision medicine at the national level

Journal of Internal Medicine, Volume 300, Issue 4, Page 397-419, October 2026.
Abstract High‐throughput sequencing has transformed clinical diagnostics of rare diseases (RD), cancer and infectious diseases by enabling the identification of disease‐causing genetic alterations and facilitating individualised treatment and care.
Anders Edsjö, Anna Lindstrand, Panagiotis Baliakas, David Gisselsson, Paula Mölling, Mia Wadelius, Åsa Johansson, Hannes Olauson, Hans Ehrencrona, Lovisa Lovmar, Christian G. Giske, Henrik Green, Ann Nordgren, Fulya Taylan, Martin Hallbeck, Erika Tång Hallbäck, Anna Green, Markus Heidenblad, Kina Höglund, Anders Jemt, Carl Mårten Lindqvist, Maria Johansson Soller, Magnus Sabel, Colum Walsh, Hartmut Vogt, Craig E. Wheelock, Martin Bergö, Jens Enoksson, Ann Ekberg Jansson, Cecilia Fagerström, Jan Holgersson, Stephanie Anja Juran, Mats G. Karlsson, Frida Lundmark, Eva Tiensuu Janson, Andreas Muranyi Scheutz, Malin Sund, Päivi Östling, Sofia Gruvberger‐Saal, Marene Landström, Malin Melin, Lars Palmqvist, Richard Palmqvist, Bianca Stenmark, Anna Wedell, Malin Karnå, Katarina Nyström, Tobias Strid, Per Sikora, Maria Johansson, Therese Fagerqvist, Mirja Carlsson Möller, Oskar Frisell, Mats Ulfendahl, Mikaela Friedman, Lucia Cavelier, Valtteri Wirta, Thoas Fioretos, Richard Rosenquist   +58 more
wiley   +1 more source

New paradigm of q-CAR drug development targeting disease-specific protein conformations. [PDF]

NPJ Drug Discov
Ye L.
europepmc   +1 more source

Phylogenetic and Structural Analysis of Miconazole Susceptibility in Malassezia pachydermatis Isolates From Dogs With Otitis Externa

Veterinary Dermatology, Volume 37, Issue 5, Page 620-629, October 2026.
Background: An increased number of dogs with unresolved yeast otitis externa (OE) after miconazole treatment was observed at a tertiary practice. Hypothesis/Objectives: To evaluate miconazole susceptibility in Malassezia pachydermatis isolates from canine OE.
Cole M. Belcher, Clarissa P. Souza, Elyas McGuire, Chien‐Che Hung, Joel D. A. Tyndall, Lois L. Hoyer   +5 more
wiley   +1 more source

Discovery of a Reversible Sub‐Picomolar Thrombin Inhibitor Using DCC

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
An ultrapotent yet fully reversible trivalent thrombin inhibitor discovered through screening a large dynamic combinatorial library (DCL) of 125 000 members of self‐assembled fragments. The innovative approach leverages size‐exclusion‐based affinity selection, coupled with MALDI‐TOF mass spectrometry readout, enabling the full workflow to be completed ...
Millicent Dockerill, Richard J. Payne, Nicolas Winssinger   +2 more
wiley   +2 more sources

High-throughput screening of a chalcone library identifies a naked-eye "traffic light" chemosensor for the discrimination of Cu²⁺ and Ni²⁺ in aqueous media. [PDF]

RSC Adv
Ciupa A.
europepmc   +1 more source

NMR‐Guided Fragment Screening Identifies Privileged Noncanonical Amino Acids for mRNA Display

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
A strategy is reported to prescreen and prioritize noncanonical amino acids as fragments prior to their use in mRNA display peptide libraries. Using MDM2 as a target, two ncAAs that bind to the Trp binding pocket in MDM2 are found by protein‐observed NMR.
Abdul J. Castillo, Clark A. Jones, Alba C. Dutra, Chelsea A. Makovsky, Sandeep Lohan, Bipasana Shakya, Sara H. Walters, Brian Fuglestad, Matthew C. T. Hartman   +8 more
wiley   +1 more source

Protocol for region-specific tumor dissection and protein extraction from a pancreatic neuroendocrine tumor mouse model. [PDF]

STAR Protoc
Vijayakurup V, Feely M, Zajac-Kaye M.
europepmc   +1 more source