Results 91 to 100 of about 4,651,731 (290)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Rapid Economic Growth at the Cost of Environment Degradation? Panel Data Evidience from BRIC Economies [PDF]
, 2008 The paper investigates whether the decline in environmental quality in BRIC economies is due to high energy consumption level which is a resultant of rapid economic growth.
Chousa, Juan Piñeiro +2 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Boston University Libraries 2016 Graduate Survey Instrument [PDF]
, 2016 In the spring of 2016, the Boston University libraries surveyed BU faculty, graduate students, and undergraduate students to determine their use of and satisfaction with library services and resources. This document shows the survey instrument emailed to
Boston University Libraries Assessment Committee
core +2 more sources
Data-Driven Consensus Protocol Classification Using Machine Learning
MathematicsThe consensus protocol plays a vital role in the performance and security of a specific Distributed Ledger Technology (DLT) solution. Currently, the traditional classification of consensus algorithms relies on subjective criteria, such as protocol ...
Marco Marcozzi +3 more
doaj +1 more source
ANALISIS KINERJA PACKET FILTERING BERBASIS MIKROTIK ROUTERBOARD PADA SISTEM KEAMANAN JARINGAN
Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 2019 Pada penelitian ini fokus pada ujicoba kinerja jaringan komputer dari sisi sistem keamanan jaringan. Ujicoba sendiri dilakukan pada jaringan komputer yang ada di Laboratorium Komputer di Universitas Bina Darma menggunakan sistem operasi Mikrotik.
Ari Muzakir, Maria Ulfa
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source