Results 101 to 110 of about 4,651,731 (290)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Communication Complexity of Entanglement-Assisted Multi-Party Computation
EntropyWe consider a quantum and a classical version of a multi-party function computation problem with n players, where players 2,…,n need to communicate appropriate information to player 1 so that a “generalized” inner product function with an appropriate ...
Ruoyu Meng, Aditya Ramamoorthy
doaj +1 more source
Man in the middle attack on HTTPS protocol
Scientific Bulletin of Naval Academy, 2020 A "man-in-the-middle" (MITM) attack occurs when an external entity intercepts communication between two systems. This can happen for any form of online communication, such as e-mail, websites social networking and web browsing. Not only does it try to listen to your private conversations, but it also steals all the information from your devices.
openaire +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Research on efficient and scalable private set intersection cardinality schemes
Tongxin xuebaoTo address the issue of high computational overhead in existing two-party private set intersection cardinality (PSI-CA) protocols, an efficient two-party PSI-CA protocol was proposed.
LI Gongli, LIU Weichen, ZHENG Dong
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Forensic Support for Abraham et al.’s BB Protocol
EntropyThe consensus protocol is a fundamental building block in distributed computing and has been widely used in blockchain systems in recent years. Paxos, introduced by Lamport, stands out as one of the most widely adopted consensus protocols and has found ...
Qidi You +5 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source