Results 61 to 70 of about 4,651,731 (290)
Boston University Libraries 2016 Undergraduate Survey Instrument [PDF]
, 2016 In the spring of 2016, the Boston University libraries surveyed BU faculty, graduate students, and undergraduate students to determine their use of and satisfaction with library services and resources. This document shows the survey instrument emailed to
Boston University Libraries Assessment Committee
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Optimizing Average-Maximum TTR Trade-off for Cognitive Radio Rendezvous
, 2015 In cognitive radio (CR) networks, "TTR", a.k.a. time-to-rendezvous, is one of the most important metrics for evaluating the performance of a channel hopping (CH) rendezvous protocol, and it characterizes the rendezvous delay when two CRs perform channel ...
Bian, Kaigui +3 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Optimal protocols for minimal work processes in underdamped stochastic thermodynamics
, 2008 For systems in an externally controllable time-dependent potential, the optimal protocol minimizes the mean work spent in a finite-time transition between two given equilibrium states.
Gomez-Marin, Alex +2 more
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An approach to application-layer DoS detection
Journal of Big Data, 2023 With the massive resources and strategies accessible to attackers, countering Denial of Service (DoS) attacks is getting increasingly difficult. One of these techniques is application-layer DoS.
Cliff Kemp +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Consensus on Transaction Commit [PDF]
, 2003 The distributed transaction commit problem requires reaching agreement on whether a transaction is committed or aborted. The classic Two-Phase Commit protocol blocks if the coordinator fails.
Gray, Jim, Lamport, Leslie
core +4 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source